TABLE 1.
Results of phase I generated by the six study sites in AST of 10 susceptible strains of M. tuberculosis
| Antimicrobial agent | BACTEC 460 medium
|
Middlebrook 7H10 agar
|
||
|---|---|---|---|---|
| Inhibitory concn (μg/ml) | Count (%)a | Inhibitory concn (μg/ml) | Count (%) | |
| Capreomycin | ≤1.25 | 59 (98.3) | 10.0 | 59 (98.3) |
| 2.5 | 1 (1.7) | |||
| Cycloserine | ≤50 | 27 (45) | 25.0 | 36 (60) |
| 60.0 | 23 (38.3) | |||
| 70.0 | 9 (15) | |||
| >70.0 | 1 (1) | |||
| Ethionamide | ≤1.25 | 59 (98.3) | 5.0 | 59 (98.3) |
| 2.5 | 1 (1.7) | |||
| Kanamycin | ≤1.25 | 48 (80) | 5.0 | 60 (100) |
| 2.5 | 12 (20) | |||
| Amikacin | ≤1.0 | 60 (100) | ≤2.0 | 54 (90) |
| >4.0 | 6 (10) | |||
| Clofazimine | ≤0.25 | 59 (98.3) | ≤0.25 | 47 (78.3) |
| 0.5 | 1 (1.7) | 0.5 | 13 (21.7) | |
| Ciprofloxacin | ≤0.5 | 46 (76.7) | ≤0.5 | 41 (68.3) |
| 1.0 | 13 (21.7) | 1.0 | 18 (30) | |
| 2.0 | 1 (1.7) | 2.0 | 1 (1.7) | |
| Ofloxacin | ≤0.5 | 21 (35) | ≤0.5 | 19 (31.7) |
| 1.0 | 34 (56.7) | 1.0 | 38 (63.3) | |
| 2.0 | 4 (6.7) | 2.0 | 3 (5) | |
| >4.0 | 1 (1.7) | |||
The count is the total number of susceptible strains.