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. Author manuscript; available in PMC: 2022 Aug 23.
Published in final edited form as: Curr Biol. 2021 Jun 25;31(16):3515–3524.e6. doi: 10.1016/j.cub.2021.05.068

Table 2. Cas1 residues that interact with canonical I-E UM are only conserved in Cas1s associated with IHF-regulated I-E CRISPRs.

See also Figure S1.

R131 R132
Subtype Leader motifs Number of Cas1s Identity Similarity dentity Similarity
I-E IHF or UM 454 57.5% 68% 71.6% 72.9%
I-E LAM, I-EA, I-EB 368 3.7% 5.4% 11.2% 13.8%
I-F IHF or UM 499 11% 11% 11.9% 22.4%