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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: J Med Chem. 2021 Apr 22;64(9):5577–5592. doi: 10.1021/acs.jmedchem.0c02041

Figure 7: Illustration of Partial Agonist Pharmacology.

Figure 7:

Three compounds demonstrated partial agonist activity at the MC4R. These compounds were described with both an EC50 and a percent activity relative to NDP-MSH (positive control and full agonist) where compound activity leveled off. For compound 2, full agonist activity was observed for the mMC3R (EC50 = 210 nM) whereas partial agonist activity was observed at the mMC4R (EC50 = 270 nM, 45% activity).