. Author manuscript; available in PMC: 2022 May 13.

Published in final edited form as: J Med Chem. 2021 Apr 26;64(9):5593–5602. doi: 10.1021/acs.jmedchem.0c01962

Table 1.

Radiosynthetic yields for [¹⁸F]-20, [¹⁸F]-21, [¹⁸F]-22, [¹⁸F]-23, [¹⁸F]-24 and [¹⁸F]-25.

Compound	[¹⁸F]-20	[¹⁸F]-21	[¹⁸F]-22	[¹⁸F]-23	[¹⁸F]-24	[¹⁸F]-25
RCY^a	29.0%	22.8%	28.8%	58.7% (1.4%^b)	66.8%	53.1%

Final step yield based on the HPLC separation with methods shown in Scheme 2.

Final step yield based on the HPLC separation with an alternate protocol shown in Scheme 3.