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. Author manuscript; available in PMC: 2022 Aug 10.
Published in final edited form as: J Am Coll Cardiol. 2021 Aug 10;78(6):625–631. doi: 10.1016/j.jacc.2021.06.010

FIGURE 2. Schematic Representation of Processes That Contribute to Thrombosis.

FIGURE 2

Tissue factor (TF) on the luminal surface of blood vessels initiates thrombin generation by forming a complex with FVII/FVIIa (left). However, thrombus growth away from the vessel wall depends on activation of FXI to amplify the process (center). In most cases, FXI is likely to be activated by thrombin, but in some situations, particularly those in which blood is exposed to artificial surfaces (right), FXIIa may be the major activator of FXI. Italics indicate cofactors. NETs = neutrophil extracellular traps; PP = polyphosphate.