Table 5.
Responsiveness of cough severity VAS by PGIC and awake cough frequency.
| Category | N | Baseline cough severity VAS, mean (SD), mm |
Week 4 cough severity VAS, mean (SD), mm |
Mean change score difference (range), mm a |
Effect size b |
|---|---|---|---|---|---|
| PGIC score | |||||
| 1 or 2 | 87 | 56.5 (20.9) | 19.2 (15.8) | −37.3 (−84.0, 26.0) | −1.8 |
| 3 | 78 | 54.1 (23.3) | 35.1 (18.9) | −18.9 (−65.0, 35.0) | −0.8 |
| 4 | 61 | 62.0 (20.6) | 56.5 (21.0) | −5.5 (−55.0, 54.0) | −0.3 |
| 5 | 5 | 77.2 (18.8) | 85.4 (14.5) | 8.2 (0, 18.0) | 0.4 |
| 6 or 7 | 4 | 56.5 (25.2) | 67.6 (33.1) | 11.1 (−18.5, 57.0) | 0.4 |
| Awake cough frequency | |||||
| ⩾30% reduction | |||||
| Responder | 126 | 55.9 (21.8) | 26.9 (20.1) | −29.0 (−84.0, 35.0) | −1.3 |
| Nonresponder | 102 | 59.2 (22.6) | 48.3 (25.4) | −10.9 (−65.0, 57.0) | −0.5 |
| ⩾50% reduction | |||||
| Responder | 79 | 57.8 (20.8) | 21.5 (16.5) | −36.2 (−84.0, 24.0) | −1.7 |
| Nonresponder | 149 | 57.2 (22.9) | 44.4 (25.1) | −12.8 (−82.0, 57.0) | −0.6 |
| ⩾70% reduction | |||||
| Responder | 52 | 56.7 (21.4) | 18.0 (15.7) | −38.8 (−84.0, 10.0) | −1.8 |
| Nonresponder | 176 | 57.6 (22.4) | 41.9 (24.6) | −15.6 (−82.0, 57.0) | −0.7 |
| ⩾ 0.30 SD reduction | |||||
| Responder | 118 | 59.3 (20.8) | 29.0 (22.1) | −30.4 (−84.0, 31.0) | −1.5 |
| Nonresponder | 110 | 55.3 (23.4) | 44.5 (25.5) | −10.8 (−73.0, 57.0) | −0.5 |
PGIC, patient global impression of change; SD, standard deviation; VAS, visual analog scale.
a
Calculated as Week 4 score − baseline score.
b
Calculated as score difference/SD of baseline score.