Figure 3.

Plasma biomarkers discriminate SPMS from RRMS. (A) Column scatter graph of plasma concentrations of MCP1/CCL2 and sCD40L of RRMS and SPMS patients. P value using Mann–Whitney test are shown above the line. (B) ROC analysis using plasma concentrations of MCP1/CCL2 and sCD40L derived from RRMS and SPMS groups. (C) Multiple logistic regression analysis using plasma concentration of sCD40L and MCP1/CCL2 derived from patients of both RRMS and SPMS groups. RRMS (n = 8), SPMS (n = 30). ROC, receiver-operating characteristic; AUC, area under curve.