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. 2021 Oct 25;13:11795735211050712. doi: 10.1177/11795735211050712

Figure 7.

Figure 7.

Summary. RRMS (green) becomes SPMS (orange) over time with increased disability; BMS (blue) does not accumulate disability despite long duration of disease. Progressing to SPMS from RRMS (indicated with a half orange/half green arrow), sCD40L and MCP1 are increased. Comparing BMS to RRMS (indicated with a half blue/half green arrow), only MCP1 is increased. Although both BMS and SPMS have long disease duration, SPMS exhibits increased sCD40L and IFNγ compared to non-progressive BMS (indicated with a half orange/half blue arrow). Both MCP1 and sCD40L were found to be correlated with EDSS.