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. 2016 Aug 9;2016(8):CD010741. doi: 10.1002/14651858.CD010741.pub2

Modi 2012.

Methods
  • Study design: RCT

  • Study duration: not reported

  • Study follow‐up period: to postoperative day 1

Participants
  • Country: India

  • Setting: private research institute associated hospital

  • Relevant health status: adult live‐donor kidney transplant recipients

  • Number: treatment group (37); control group (37)

  • Mean age ± SD (years): not reported

  • Sex (M/F): not reported

  • Cold ischaemia time (minutes): not reported

  • Warm ischaemia time (minutes): not reported

  • Exclusion criteria: severe cardiovascular disease, liver dysfunction, diabetes mellitus, preoperative serum potassium level > 5.5 mEq/L

Interventions Treatment group
  • Lactated ringers

    • Intraoperative IV fluid titrated to keep CVP at 12 to 15 mm Hg


Control group
  • Normal saline

    • Intraoperative IV fluid titrated to keep CVP at 12 to 15 mm Hg


Post‐operative fluid
  • Not reported


Baseline immunosuppression
  • Induction: methylprednisolone

  • Maintenance: not reported

Outcomes
  • Acid‐base status: mean difference in blood pH, serum chloride concentration, and serum bicarbonate concentration at the end of surgery compared to baseline

Notes
  • Funding source: no information on funding sources was provided

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "A computer randomization program was used for patient group assignments." Page 135, paragraph 2
Allocation concealment (selection bias) Unclear risk Information on allocation concealment was not reported
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk "The solutions were supplied by our hospital pharmacy after completely covering each bag with opaque tape to ensure blinding to study personnel and patients." Page 135, paragraph 2
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Specific information on masking of outcome and data assessors was not reported
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk No information on intention‐to‐treat principle or missing outcome date reported
Selective reporting (reporting bias) Unclear risk No trial registration or published protocol
Other bias Unclear risk Published as a letter to the editor only. No information on funding reported