Skip to main content
. 2021 Oct 14;6(42):28410–28420. doi: 10.1021/acsomega.1c04825

Table 1. Target Proteins of OA against OP in the Protein Interaction Network.

no. protein names gene symbol number of neighboring proteins no. protein names gene symbol number of neighboring proteins
1 mitogen-activated protein kinase 1 MAPK1 20 22 prostaglandin-endoperoxide synthase 1 PTGS1 3
2 tumor protein P53 TP53 18 23 superoxide dismutase 1 SOD1 3
3 caspase 3 CASP3 16 24 topoisomerase I TOP1 3
4 interleukin-6 IL6 16 25 arachidonate-5-lipoxygenase ALOX5 2
5 Jun proto-oncogene JUN 15 26 apolipoprotein B APOB 2
6 tumor necrosis factor TNF 14 27 nicotinamide phosphoribosyltransferase NAMPT 2
7 prostaglandin-endoperoxide synthase 2 PTGS2 12 28 protein tyrosine phosphatase nonreceptor type 1 PTPN1 2
8 myelocytomatosis oncogene MYC 11 29 protein tyrosine phosphatase receptor type F PTPRF 2
9 nitric oxide synthase 3 NOS3 11 30 retinoic acid receptor alpha RARA 2
10 interleukin 1 beta IL1B 10 31 retinoic acid receptor beta RARB 2
11 peroxisome proliferator-activated receptor gamma PPARG 10 32 G protein-coupled bile acid receptor 1 GPBAR1 1
12 catalase CAT 9 33 3-hydroxy-3-methylglutaryl-CoA reductase HMGCR 1
13 estrogen receptor 1 ESR1 9 34 hydroxysteroid 11-beta dehydrogenase 1 HSD11B1 1
14   BCL2 8 35 prostaglandin I2 receptor PTGIR 1
15 caspase 8 CASP8 8 36 RAR-related orphan receptor C RORC 1
16 cytochrome C, somatic CYCS 8 37 nuclear receptor subfamily 1 group H member 2 NR1H2 0
17 mechanistic target of rapamycin kinase MTOR 7 38 DNA polymerase beta POLB 0
18 nuclear factor (erythroid-derived 2)-like 2 NFE2L2 7 39 phosphodiesterase 4D PDE4D 0
19 fatty acid synthetase FAS 4 40 protein tyrosine phosphatase nonreceptor type 2 PTPN2 0
20 peroxisome proliferator-activated receptor alpha PPARA 4 41 acid phosphatase 1 ACP1 0
21 NADPH quinone acceptor oxidoreductase 1 NQO1 3 42 CD81 antigen (target of antiproliferative antibody 1) CD81 0