. 2021 Oct 11;6(42):28366–28372. doi: 10.1021/acsomega.1c04550

Table 2. Optimization of the Conditions for Hydroxamination of 2^a.

entry	reagent	base	solvent	time (h)	yield
1.	NH₂OH·HCl		MeOH	48
2.	NH₂OH·HCl		EtOH	48
3.	NH₂OH·HCl		i-PrOH	48
4.	NH₂OH·HCl		DMF	48	trace
5.	NH₂OH·HCl		DMSO	48
6.	NH₂OH·HCl	NaHCO₃	MeOH	36	67%
7.	NH₂OH·HCl	Na₂CO₃	MeOH	30	51%
8.	NH₂OH·HCl	K₂CO₃	MeOH	34	56%
9.	NH₂OH·HCl	NaOAc	MeOH	48
10.	(NH₂OH)₂·H₂SO₄		MeOH	48
11.	NH₂OH		MeOH	01	80%

Isolated yields are reported; MeOH = methanol, EtOH = ethanol, i-PrOH = isopropanol, DMF = N,N-dimethylformamide, and DMSO = dimethyl sulfoxide.

Table 2. Optimization of the Conditions for Hydroxamination of 2a.