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. 2021 Oct 18;6(42):28441–28454. doi: 10.1021/acsomega.1c05283

Table 3. Stepwise Reaction of 1a–c and 11 to 12a–c, 13a–c, and 14a–c.

entry 1 R1 12 yield (%) 13 yield (%) 14 yield (%)
1 1a H 12a 82a 13a 99 14a 61c
2 1b Me 12b 73a 13b 91 14b 89c
3 1c Cl 12c 70b 13c 95 14c 74d
a

The reaction with piperidine (0.2 equiv) in benzene at r.t.

b

The reaction with piperidine (0.2 equiv) and acetic acid (1.0 equiv) in benzene at 80 °C.

c

The reaction with DDQ at r.t. in dichloromethane.

d

The reaction with DDQ at 80 °C in 1,2-dichloroethane.