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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Neuropharmacology. 2021 Jul 9;197:108698. doi: 10.1016/j.neuropharm.2021.108698

Figure 3. Alcohol drinking produces a shift in microglial cell morphology to a more reactive state in the in the mPFC of adolescent male and female rats.

Figure 3.

Automated morphological analysis of microglial cells was conducted using Nikon NIS-Elements Advanced Research software. We obtained a measurement of total branching points per microglial cell in the mPFC. Alcohol shifted the population distribution of microglial cell morphology to the left in male and female rats, indicating a more “alert” structure in which cellular branching is more retracted in these animals (C, D, n=6 rats for each sex and treatment group. Two-sample Kolmogorov-Smirnov test, both ps < 0.05).