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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Neuropharmacology. 2021 Jul 9;197:108698. doi: 10.1016/j.neuropharm.2021.108698

Figure 5. Voluntary binge drinking increased gene expression of pro-inflammatory factors more robustly in males than in females in the mPFC.

Figure 5.

(A) Schematic showing the dissected portion of the mPFC used for qPCR analysis. (B) Alcohol drinking increased expression of the gene that encodes for IL1b, a pro-inflammatory cytokine, in both males and females (p < 0.001). (C) Adolescent drinking also increased expression of Tlr4 gene, which encodes for the receptor that activates the pro-inflammatory cascade but this effect was only observed in males (p < 0.01). Data are expressed as mean ± SEM (n = 5–6 rats for each sex and treatment group).