Table 2.
Patterns of failure in the entire cohort.
| Site of the first progression | Deferred RT (n = 94) | Upfront RT (n = 104) | p-value |
|---|---|---|---|
| N (%) | N (%) | ||
| Intracranial site alone | 68 (72.3) | 39 (37.5) | <0.001 |
| Local | 33 (48.5) | 15 (38.5) | 0.314 |
| Distant | 18 (26.5) | 18 (46.2) | 0.020 |
| Concurrent | 16 (23.5) | 6 (15.4) | 0.316 |
| None | 1 (1.5) | 0 (0.0) | 0.532 |
| Extracranial site alone | 15 (16.0) | 49 (47.1) | <0.001 |
| Primary | 2 (13.3) | 4 (8.2) | 0.618 |
| Regional | 3 (20.0) | 5 (10.2) | 0.377 |
| Metastases | 6 (40.0) | 26 (53.1) | 0.376 |
| Concurrent | 4 (26.7) | 14 (28.6) | 1.000 |
| Both intra and extra cranial site | 3 (3.2) | 8 (7.7) | 0.167 |
| None | 8 (8.5) | 8 (7.7) | 0.637 |
N, number; BM, brain metastases; KPS, Karnofsky Performance Score; TKI, tyrosine kinase inhibitor; RT, radiation therapy.