TABLE 2.

Gene expression analyzed by RT-qPCR in models treated with 100 ng/ml RANK + DAPT for 24 h

Genea	Terminal ileum		Cecum		Colon
	FCb	P valuec	FC	P value	FC	P value
LRG5	1.1	NS	4.7	NS	0.4	<0.005
SPIB	213.9	<0.005	8.7	NS	14,625.1	<0.005
KLF4	0.7	NS	0.6	NS	0.8	NS
ESE1	0.9	NS	0.4	NS	0.7	<0.05
MUC2	2.6	NS	0.2	NS	1.2	NS
CGA	0.3	NS	0.5	NS	1.7	NS
NEUROD	BDL		BDL		1.2	NS
SPDEF	0.8	NS	0.4	NS	0.3	<0.005
SOX9	1.2	NS	0.3	NS	1.3	<0.05
LYZ	1.1	NS	0.2	NS	0.6	<0.005
OCLDN	1.2	NS	0.4	NS	1.1	NS
SIM	1.1	NS	0.2	NS	1.0	NS

^aPlease refer to Materials and Methods for information on each gene.

^bFold change (FC) reflects the fold change in gene expression in the 100 ng/ml RANKL + DAPT treatments relative to the DAPT treatment at 24 h. BDL, below detection level. Note that the SPIB expression levels correspond to the data presented in Fig. 2.

^cStatistical significance determined with the nonparametric Mann-Whitney test. NS, not significant.