Table 1.
Baseline characteristics stratified by change to treatment [n (%)]
| No change | Changed | Total | ||
|---|---|---|---|---|
| Total n (%) | 1025 (66.0) | 528 (34.0) | 1553 | |
| Age (years) | <70 | 405 (39.5) | 203 (38.4) | 608 (39.2) |
| ≥70 | 610 (59.5) | 325 (61.6) | 935 (60.2) | |
| Missing | 10 (1.0) | 0 (0.0) | 10 (0.6) | |
| Gender | Female | 524 (51.1) | 238 (45.1) | 762 (49.1) |
| Male | 495 (48.3) | 290 (54.9) | 785 (50.5) | |
| Missing | 6 (0.6) | 0 (0.0) | 6 (0.4) | |
| Performance status | 0 | 118 (11.5) | 96 (18.2) | 214 (13.8) |
| 1 | 509 (49.7) | 309 (58.5) | 818 (52.7) | |
| 2–3 | 390 (38.0) | 123 (23.3) | 513 (33.0) | |
| Missing | 8 (0.8) | 0 (0.0) | 8 (0.5) | |
| Clinical frailty scale | 1 | 18 (1.8) | 14 (2.7) | 32 (2.1) |
| 2 | 72 (7.0) | 59 (11.2) | 131 (8.4) | |
| 3 | 143 (14.0) | 115 (21.8) | 258 (16.6) | |
| 4 | 101 (9.9) | 62 (11.7) | 163 (10.5) | |
| 5 | 56 (5.5) | 22 (4.2) | 78 (5.0) | |
| 6 | 27 (2.6) | 10 (1.9) | 37 (2.4) | |
| 7 | 7 (0.7) | 1 (0.2) | 8 (0.5) | |
| Missing | 601 (58.6) | 245 (46.4) | 846 (54.5) | |
| Smoking status | Current smoker | 298 (29.1) | 148 (28.0) | 446 (28.7) |
| Ex-smoker | 594 (58.0) | 317 (60.0) | 911 (58.7) | |
| Never smoker | 29 (2.8) | 22 (4.2) | 51 (3.3) | |
| Missing | 104 (10.1) | 41 (7.8) | 145 (9.3) | |
| Histology | NSCLC | 576 (56.2) | 330 (62.5) | 906 (58.3) |
| SCLC | 87 (8.5) | 70 (13.3) | 157 (10.1) | |
| Radiological diagnosis | 354 (34.5) | 128 (24.2) | 482 (31.0) | |
| Missing | 8 (0.8) | 0 (0.0) | 8 (0.5) | |
| Stage | I | 473 (46.1) | 189 (35.8) | 662 (42.6) |
| II | 164 (16.0) | 71 (13.4) | 235 (15.1) | |
| III | 380 (37.1) | 265 (50.2) | 645 (41.5) | |
| Missing | 8 (0.8) | 3 (0.6) | 11 (0.7) | |
| Region | North West England | 166 (16.2) | 159 (30.1) | 325 (20.9) |
| Yorkshire & North East England | 161 (15.7) | 106 (20.1) | 267 (17.2) | |
| South East England | 151 (14.7) | 77 (14.6) | 228 (14.7) | |
| London | 46 (4.5) | 17 (3.2) | 63 (4.1) | |
| South West England | 50 (4.9) | 28 (5.3) | 78 (5.0) | |
| Midlands | 123 (12.0) | 49 (9.3) | 172 (11.1) | |
| Northern Ireland | 88 (8.6) | 30 (5.7) | 118 (7.6) | |
| Wales | 63 (6.1) | 42 (8.0) | 105 (6.8) | |
| Scotland | 177 (17.3) | 20 (3.8) | 197 (12.7) | |
| IHD | No IHD | 819 (79.9) | 439 (83.1) | 1258 (81.0) |
| IHD | 206 (20.1) | 89 (16.9) | 295 (19.0) | |
| CHF | No CHF | 964 (94.0) | 506 (95.8) | 1470 (94.7) |
| CHF | 61 (6.0) | 22 (4.2) | 83 (5.3) | |
| Cardiac arrhythmia | No arrhythmia | 912 (89.0) | 471 (89.2) | 1383 (89.1) |
| Arrhythmia | 113 (11.0) | 57 (10.8) | 170 (10.9) | |
| Hypertension | No hypertension | 660 (64.4) | 354 (67.0) | 1014 (65.3) |
| Hypertension | 365 (35.6) | 174 (33.0) | 539 (34.7) | |
| COPD | No COPD | 574 (56.0) | 312 (59.1) | 886 (57.1) |
| COPD | 451 (44.0) | 216 (40.9) | 667 (42.9) | |
| CKD | No CKD | 961 (93.8) | 507 (96.0) | 1468 (94.5) |
| CKD | 64 (6.2) | 21 (4.0) | 85 (5.5) | |
| Diabetes | No diabetes | 859 (83.8) | 449 (85.0) | 1308 (84.2) |
| Diabetes | 166 (16.2) | 79 (15.0) | 245 (15.8) | |
| Stroke/TIA | No stroke | 930 (90.7) | 493 (93.4) | 1423 (91.6) |
| Stroke | 95 (9.3) | 35 (6.6) | 130 (8.4) | |
| Dementia | No dementia | 1011 (98.6) | 522 (98.9) | 1533 (98.7) |
| Dementia | 14 (1.4) | 6 (1.1) | 20 (1.3) | |
| Previous malignancy | No previous malignancy | 772 (75.3) | 423 (80.1) | 1195 (76.9) |
| Previous malignancy | 253 (24.7) | 105 (19.9) | 358 (23.1) |
CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; CKD, chronic kidney disease; IHD, ischaemic heart disease; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; TIA, transient ischaemic attack.