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. 2021 Oct 28;11(4):413–425. doi: 10.1007/s44197-021-00009-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Three-dimensional antigenic map of influenza A(H1N1)pdm09 (on the left) and A(H3N2) (on the right) viruses that circulated in Russia in the season 2018–2019. NOTE: grey or red spheres indicated with red symbols—reference antigens; grey cubes/squares indicated with blue symbols—reference antisera; green spheres indicated with bold black symbols—old test antigens (2013–2017); orange circles—test antigens season 2018–2019. One map square represents a twofold difference in HI titre