FIG 1.

SalmoFresh delays the burden of Salmonella after challenge in OMM¹² mice. (A) Experimental design. Groups of 4 to 6 OMM¹² mice were orally administered PBS or SalmoFresh (1 × 10⁹ PFU) on the indicated days. On day 2, mice were challenged with ST784 (1 × 10⁸ CFU) or a PBS control as indicated. (B) Mice were weighed daily. Shown are the percentages of weight loss compared to starting weights of OMM¹² mice over time. (C and D) The amounts of ST784 (CFU) (C) and phages (PFU) (D) in OMM¹² mouse feces were quantitated daily (day 2 corresponds to 3 h after ST784 challenge). (E and F) Intestinal organs were collected on day 6 and homogenized, and the amounts of ST784 (CFU) (E) and phage (PFU) (F) were quantitated. Statistical analyses are described in Materials and Methods and reported in Table S1.