FIG 2.

FOP reduces Salmonella burden in vivo. (A) Experimental design. OMM¹² mice were orally administered PBS or FOP (1 × 10⁹ PFU) on the indicated days. On day 2, all mice were challenged with strain ST784 (1 × 10⁸ CFU). Stars indicate the time points at which samples were taken for the 16S rRNA gene analysis reported in Fig. 3. (B) Mice were weighed daily. Shown are the percentages of weight loss compared to starting weights of OMM¹² mice over time. (C and D) The amounts of ST784 (CFU) (C) and phages (PFU) (D) in OMM¹² mouse feces were quantitated daily (day 2 corresponds to 3 h after ST784 challenge). (E and F) Intestinal organs were collected on day 6, and the amounts of ST784 (CFU) (E) and phages (PFU) quantitated. Statistical analyses are described in Materials and Methods and reported in Table S2.