TABLE 1.
SalmoFresh reduces disease symptoms associated with the burden of Salmonella in OMM12 mice
| Treatment groupa | No. of mice that wereb: |
Treatment |
Challenge |
Clinical signs and symptoms on dayd: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | F | SFc | PBS | ST784 | PBS | 0 | 1 | 2 | 3 | 4 | 5 | 6 | |
| ST784 SalmoFresh | 2 | − | + | − | + | − | None | None | None | None | None | Mild | Mod |
| − | 4 | + | − | + | − | None | None | None | None | None | None | Mod | |
| PBS SalmoFresh | 2 | − | + | − | − | + | None | None | None | None | None | None | None |
| − | 3 | + | − | − | + | None | None | None | None | None | None | None | |
| ST784 PBS | 2 | − | − | + | + | − | None | None | None | None | None | Mod | Mod |
| − | 4 | − | + | + | − | None | None | None | None | Mod | Mod | Sev | |
a
Treatment groups were as shown in Fig. 1A.
b
M, male; F, female.
c
SF, SalmoFresh.
d
Clinical signs and symptoms over time (days 0 to 6) are scored based on animal behavior (e.g., activity, hunching) and consistency of fecal pellets (e.g., formed/no liquid, formed/liquid, liquid) as follows: None, no signs of disease; Mild, 50% of animals in group exhibited mild signs of disease; Mod, all animals in group exhibited moderate disease; Sev, all animals in group exhibited severe disease.