TABLE 2.
FOP reduces disease symptoms associated with the burden of Salmonella in OMM12 mice
| Treatment groupa | No. of mice that wereb: |
Treatment |
Clinical signs and symptoms on dayc: |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| M | F | FOP | PBS | 0 | 1 | 2 | 3 | 4 | 5 | 6 | |
| ST784 FOP | 6 | − | + | − | None | None | None | None | None | None | Mild |
| − | 8 | + | − | None | None | None | None | None | None | Mild | |
| ST784 PBS | 6 | − | − | + | None | None | None | None | None | Mod | Sev |
| − | 5 | − | + | None | None | None | None | Mild | Mod | Mod | |
a
Treatment groups were as shown in Fig. 2.
b
M, male; F, female.
c
Clinical signs and symptoms over time (days 0 to 6) are scored based on animal behavior (e.g., activity, hunching) and consistency of fecal pellets (e.g., formed/no liquid, formed/liquid, liquid) as follows: None, indicates no signs of disease; Mild, indicates 50% of animals in group exhibited mild signs of disease; Mod, indicates all animals in group exhibited moderate disease; Sev, indicates 50% of animals in group exhibited severe disease.