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. 2021 Jul 28;9(1):10.1128/spectrum.00496-21. doi: 10.1128/spectrum.00496-21

TABLE 1.

Differentially abundant human proteins identified in YopJC172A Y. pseudotuberculosis-infected THP-1 macrophages in comparison to wild-type Yersinia-infected macrophagesa

Symbol Gene name UniProt accession no. P Fold change Location Molecule type
DYNC1LI1 Dynein cytoplasmic 1 light intermediate chain 1 Q9Y6G9 0.021 −14.286 Cytoplasm Other
PUS1 Pseudouridine synthase 1 Q9Y606 0.021 −14.286 Nucleus Enzyme
UFD1 Ubiquitin recognition factor in ER associated degradation 1 Q92890 0.034 −12.5 Cytoplasm Peptidase
EEF1E1 Eukaryotic translation elongation factor 1 epsilon 1 O43324 0.004 −3.333 Cytoplasm Translation regulator
ACADS Acyl-CoA dehydrogenase short chain P16219 0.021 −2.5 Cytoplasm Enzyme
CAPRIN1 Cell cycle-associated protein 1 Q14444 0.013 −2.5 Plasma membrane Other
H1-10 H1.10 linker histone Q92522 0.043 −2.5 Nucleus Other
LUC7L3 LUC7 like 3 pre-mRNA splicing factor O95232 0.042 −2.5 Nucleus Other
USP14 Ubiquitin-specific peptidase 14 P54578 0.002 −2.5 Cytoplasm Peptidase
APBB1IP Amyloid beta precursor protein binding family B member 1 interacting protein Q7Z5R6 0.046 −2 Cytoplasm Other
ARF1 ADP ribosylation factor 1 P84077 0.0041 −2 Cytoplasm enzyme
FCGR1A Fc fragment of IgG receptor Ia P12314 0.047 −2 Plasma membrane Transmembrane receptor
HIGD1A HIG1 hypoxia-inducible domain family member 1A Q9Y241 0.0076 −2 Cytoplasm Other
LAMTOR1 Late endosomal/lysosomal adaptor, MAPK, and MTOR activator 1 Q6IAA8 0.044 −2 Plasma membrane Other
MEPCE Methylphosphate capping enzyme Q7L2J0 0.039 −2 Other Enzyme
TAOK3 TAO kinase 3 Q9H2K8 0.019 −2 Cytoplasm Kinase
TERF2IP TERF2 interacting protein Q9NYB0 0.045 −2 Nucleus Other
TIA1 TIA1 cytotoxic granule associated RNA binding protein P31483 0.0059 −2 Nucleus Other
TMX1 Thioredoxin-related transmembrane protein 1 Q9H3N1 0.017 −2 Cytoplasm Enzyme
LGALS9 Galectin 9 O00182 0.006 −1.667 Plasma membrane Other
MAPK1 Mitogen-activated protein kinase 1 P28482 0.031 −1.667 Cytoplasm Kinase
PSAT1 Phosphoserine aminotransferase 1 Q9Y617 0.026 −1.667 Cytoplasm Enzyme
SCAMP3 Secretory carrier membrane protein 3 O14828 0.0018 −1.667 Cytoplasm Transporter
SIRPA Signal regulatory protein alpha P78324 0.015 −1.667 Plasma membrane Phosphatase
SNX9 Sorting nexin 9 Q9Y5X1 0.0054 −1.667 Cytoplasm Transporter
TARS1 Threonyl-tRNA synthetase 1 P26639 0.011 −1.667 Nucleus Enzyme
TSN Translin Q15631 0.03 −1.667 Nucleus Other
ARPC2 Actin-related protein 2/3 complex subunit 2 O15144 0.049 1.5 Cytoplasm Other
FTL Ferritin light chain P02792 0.0081 1.5 Cytoplasm Enzyme
THRAP3 Thyroid hormone receptor associated protein 3 Q9Y2W1 0.045 1.5 Nucleus Transcription regulator
LMNB2 Lamin B2 Q03252 0.0029 1.6 Nucleus Other
NUP155 Nucleoporin 155 O75694 0.034 1.6 Nucleus Other
SCLY Selenocysteine lyase Q96I15 0.0001 1.6 Cytoplasm Enzyme
HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U like 2 Q1KMD3 0.029 1.7 Nucleus Other
EIF3I Eukaryotic translation initiation factor 3 subunit I Q13347 0.026 1.8 Cytoplasm Translation regulator
GATM Glycine amidinotransferase P50440 0.038 1.8 Cytoplasm Enzyme
HNRNPL Heterogeneous nuclear ribonucleoprotein L P14866 0.033 1.8 Nucleus Other
NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 Q9UI09 0.042 1.8 Cytoplasm Enzyme
PCYOX1L Prenylcysteine oxidase 1 like Q8NBM8 0.026 1.8 Other Other
RPL17 Ribosomal protein L17 P18621 0.035 1.8 Cytoplasm Other
TARS2 Threonyl-tRNA synthetase 2, mitochondrial Q9BW92 0.026 1.8 Cytoplasm Enzyme
C1QBP Complement C1q binding protein Q07021 0.032 1.9 Cytoplasm Transcription regulator
DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 Q9UBS4 0.031 1.9 Cytoplasm Other
H6PD Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase O95479 0.026 1.9 Cytoplasm Enzyme
PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Q02809 0.037 2.1 Cytoplasm Enzyme
MOGS Mannosyl-oligosaccharide glucosidase Q13724 0.029 2.2 Cytoplasm Enzyme
NUP205 Nucleoporin 205 Q92621 0.021 2.2 Nucleus Other
ITGA4 Integrin subunit alpha 4 P13612 0.036 2.3 Plasma membrane Transmembrane receptor
NUP214 Nucleoporin 214 P35658 0.038 2.3 Nucleus Transporter
PCYT1A Phosphate cytidylyltransferase 1, choline, alpha P49585 0.038 2.3 Cytoplasm Enzyme
PREP Prolyl endopeptidase P48147 0.025 2.3 Cytoplasm Peptidase
RANBP3 RAN binding protein 3 Q9H6Z4 0.04 2.4 Nucleus Other
CLTA Clathrin light chain A P09496 0.049 2.5 Plasma membrane Other
AGO2 Argonaute RISC catalytic component 2 Q9UKV8 0.044 2.7 Cytoplasm Translation regulator
MRPS7 Mitochondrial ribosomal protein S7 Q9Y2R9 0.044 2.7 Cytoplasm Other
PDS5A PDS5 cohesin associated factor A Q29RF7 0.021 2.7 Nucleus Other
ALOX5AP Arachidonate 5-lipoxygenase activating protein P20292 0.0044 2.8 Plasma membrane Other
BCLAF1 BCL2 associated transcription factor 1 Q9NYF8 0.048 3 Nucleus Transcription regulator
HDHD2 Haloacid dehalogenase like hydrolase domain containing 2 Q9H0R4 0.0016 3 Cytoplasm Other
CALU Calumenin O43852 0.024 3.1 Cytoplasm Other
CBX3 Chromobox 3 Q13185 0.022 3.1 Nucleus Transcription regulator
ZC3H4 Zinc finger CCCH-type containing 4 Q9UPT8 0.048 3.1 Nucleus Transcription regulator
TM9SF4 Transmembrane 9 superfamily member 4 Q92544 0.0087 3.3 Cytoplasm Transporter
COX17 Cytochrome c oxidase copper chaperone COX17 Q14061 0.036 3.5 Cytoplasm Enzyme
NDUFS2 NADH:ubiquinone oxidoreductase core subunit S2 O75306 0.04 3.7 Cytoplasm Enzyme
NDUFA4 NDUFA4 mitochondrial complex associated O00483 0.016 4.1 Cytoplasm Enzyme
PPIF Peptidylprolyl isomerase F P30405 0.0026 4.1 Cytoplasm Enzyme
GGH Gamma-glutamyl hydrolase Q92820 0.034 4.4 Cytoplasm Peptidase
RALY RALY heterogeneous nuclear ribonucleoprotein Q9UKM9 0.045 4.8 Nucleus Transcription regulator
TSFM Ts translation elongation factor, mitochondrial P43897 0.022 4.8 Cytoplasm Translation regulator
MRPL45 Mitochondrial ribosomal protein L45 Q9BRJ2 0.021 4.9 Cytoplasm Other
PPP5C Protein phosphatase 5 catalytic subunit P53041 0.021 4.9 Nucleus Phosphatase
TRA2B Transformer 2 beta homolog P62995 0.02 6.1 Nucleus Other
GUK1 Guanylate kinase 1 Q16774 0.0001 8.8 Cytoplasm Kinase
ATAD3A ATPase family AAA domain containing 3A Q9NVI7 0.019 12 Cytoplasm Other
EDF1 Endothelial differentiation related factor 1 O60869 0.019 12 Nucleus Transcription regulator
GOLGB1 Golgin B1 Q14789 0.019 12 Cytoplasm Other
IDH3B Isocitrate dehydrogenase (NAD+) 3 noncatalytic subunit beta O43837 0.019 12 Cytoplasm Enzyme
RPS6KA3 Ribosomal protein S6 kinase A3 P51812 0.025 14 Cytoplasm Kinase
GET3 Guided entry of tail-anchored proteins factor 3, ATPase O43681 0.0001 18 Nucleus Transporter
MRPL39 Mitochondrial ribosomal protein L39 Q9NYK5 0.0001 18 Cytoplasm Other
PFDN4 Prefoldin subunit 4 Q9NQP4 0.0001 18 Cytoplasm Other
HAX1 HCLS1-associated protein X-1 O00165 0.0021 21 Cytoplasm Other
RSL1D1 Ribosomal L1 domain containing 1 O76021 0.028 21 Nucleus Other
SQLE Squalene epoxidase Q14534 0.0021 21 Cytoplasm Enzyme
JUN Jun proto-oncogene, AP-1 transcription factor subunit P05412 0.0014 23 Nucleus Transcription regulator
RNASE2 RNase A family member 2 P10153 0.0066 26 Cytoplasm Enzyme
NDRG1 N-myc downstream regulated 1 Q92597 0.02 29 Nucleus Kinase
TOMM40 Translocase of outer mitochondrial membrane 40 O96008 0.016 35 Cytoplasm Ion channel
a

The table includes a gene designation, the Entrez gene name, the UniProt accession number, the experimental P value calculated using a Student t test, the experimental fold change value calculated based on the normalized and weighted spectral count (YopJC172A Yersinia:wild-type Yersinia), the protein location, and the molecule type.