TABLE 1.

Individual-level comorbidity and symptom data for the 23 repeatedly positive patients^a

Days between positive SARS-CoV-2 tests	Patient	Comorbiditiesb	Symptom(s) of COVID-19 episode 1	Symptom(s) of COVID-19 episode 2
≥90	2	HTN, HLD	SOB, cough, fever, chest pain, pneumonia, acute respiratory failure w/hypoxia, bradycardia	None
	8	Nicotine, AFib, HTN, Pacemaker, Long QT, h/o VTE, long-term AC	None	SOB, bradycardia
	14	Nicotine, HIV, alcoholic cirrhosis, protein-calorie malnutrition, alcohol dependence, TB	Low back pain	Fever
	19	HTN, alcohol dependence	Fever, pneumonia, hypoxia, AKI	Fever, respiratory failure w/hypoxia, encephalopathy, AKI
60–89	1	Insulin-dependent DM2 w/CKD, COPD, nicotine, AFib, HTN, HLD, NSTEMI, pacemaker, long QT, h/o VTE, long-term AC, ESRD on HD, retroperitoneum cancer	SOB, diarrhea, weakness, low back pain, pneumonia, acute respiratory failure w/hypoxia, ARDS, altered mental status, metabolic encephalopathy, fluid overload, ventricular tachycardia	Acute respiratory failure w/hypoxia, ventricular tachycardia
	3	Kidney-heart transplant, rheumatoid arthritis, protein-calorie malnutrition	Cough, chest pain, pneumonia, AKI, tachycardia	SOB, diarrhea, respiratory failure w/hypoxia, AKI, tachycardia
	4	HTN, HLD, HIV, alcoholic cirrhosis w/ascites	Fever, tachycardia	SOB, fever, AKI, tachycardia, acute embolism and thrombosis
	5	Prostate cancer, alcoholic cirrhosis w/ascites, alcohol abuse, h/o pulmonary TB	Cough, fever, headache, chest pain, tachycardia, acute embolism and thrombosis	Chest pain, tachycardia, acute embolism and thrombosis
	6	HTN, HLD, old MI, NSTEMI, long QT, ESRD on HD, protein-calorie malnutrition, OSA, thyroid cancer	Fever, diarrhea, pneumonia, acute respiratory failure w/hypoxia, ARDS, ventilator dependence, AKI, encephalopathy, tachycardia, severe sepsis w/shock, acute embolism and thrombosis	Diarrhea, pneumonia, acute respiratory failure w/hypoxia, ARDS, AKI, tachycardia, sepsis w/shock, acute embolism and thrombosis
	7	Insulin-dependent DM2 w/CKD, AFib, HTN, HLD, long QT, long-term AC, CKD, kidney transplant, protein-calorie malnutrition	SOB, cough, headache, pneumonia, acute respiratory failure with hypoxia, ARDS, AKI, encephalopathy, fluid overload, sepsis w/shock, acute embolism and thrombosis	Fever, pneumonia, acute respiratory failure w/hypoxia, ventilator dependence, AKI, fluid overload, sepsis w/shock
	9	AFib, HTN, HLD, old MI, pacemaker, long QT, long-term AC, CKD, breast cancer, protein-calorie malnutrition	Weakness, pneumonia, acute respiratory failure w/hypoxia, AKI	Diarrhea, weakness, pneumonia, acute respiratory failure w/hypoxia, AKI
	10	HTN, CLL w/o remission	SOB, fever, headache	None
	11	Insulin-dependent DM2, nicotine, HTN, HLD, old MI, cirrhosis	Altered mental status	Weakness, AKI, metabolic encephalopathy, altered mental status, bradycardia
	12	AFib, HTN, HLD, CKD, protein-calorie malnutrition	SOB, diarrhea, pneumonia, acute respiratory failure w/hypoxia, ARDS, AKI, encephalopathy, tachycardia, sepsis w/shock	SOB, diarrhea, chest pain, pneumonia, acute respiratory failure w/hypoxia, ARDS, AKI, encephalopathy, tachycardia, sepsis w/shock
	13	AFib, HTN, HLD, long-term AC, cirrhosis, protein-calorie malnutrition	Pneumonia, acute respiratory failure w/hypoxia, tachycardia	Diarrhea, chest pain, pneumonia, acute respiratory failure w/hypoxia, AKI, encephalopathy, sepsis w/shock
	15	Insulin-dependent DM2 w/CKD, HTN, HLD, old MI, ESRD on HD, heart transplant	Fever, headache, diarrhea, weakness, low back pain, pneumonia, acute respiratory failure w/hypoxia, metabolic encephalopathy, fluid overload	Weakness, pneumonia, acute respiratory failure w/hypoxia, encephalopathy, fluid overload, tachycardia, sepsis w/o shock
	16	HTN, HLD	Weakness, pneumonia, AKI, metabolic encephalopathy	Fever, weakness, chest pain, pneumonia, tachycardia
	17	HTN, protein-calorie malnutrition	Pneumonia, acute respiratory failure w/hypoxia, AKI, encephalopathy	SOB, pneumonia
	18	Esophageal cancer	None	None
	20	Insulin-dependent DM2 w/CKD, nicotine, HTN, ESRD on HD, HIV	Fever, headache, chest pain, acute respiratory failure w/hypoxia	Chest pain
	21	Nicotine, long QT	Low back pain	Low back pain
	22	Monoclonal gammopathy, respiratory TB, histoplasmosis, blastomycosis	None	Fever
	23	COPD, nicotine	Pneumonia	SOB, pneumonia, acute respiratory failure w/hypoxia

^aData are based on manual review of ICD-10 codes within 30 days before and after the index date and the second positive test date. MI, myocardial infarction; AC, anticoagulation; HTN, hypertension; HDL, hyperlipidemia; SOB, shortness of breath; DM2, type 2 diabetes mellitus; CKD, chronic kidney disease; AFib, atrial fibrillation; VTE, venous thromboembolism; ESRD, end-stage renal disease; HD, hemodialysis; TB, tuberculosis; OSA, obstructive sleep apnea; AKI, acute kidney injury; ARDS, acute respiratory distress syndrome; CLL, chronic lymphocytic leukemia; COPD, chronic obstructive pulmonary disease.

^bBold text denotes an immunocompromising condition.