TABLE 1.
Nucleotide and amino acid residue changes of the Finnish isolates in comparison to the reference SARS-CoV-2 Wuhan-Hu-1 sequence
| Isolate | Nt positiona | Regionb | Nt change | AA change | Lineages sharing the change |
|---|---|---|---|---|---|
| hCoV-19/Finland/1/2020 | 21,707 | S | C → T | H49Y | |
| hCoV-19/Fin-25/2020 | 241 | 5′-UTR | C → T | B.1 | |
| 3,037 | Nsp3c | C → T | B.1 | ||
| 14,408 | Nsp12 | C → T | P314L | B.1 | |
| 23,403 | S | A → G | D614G | B.1 | |
| 26,187 | Orf3a | T → C | |||
| hCoV-19/Finland/3/2020 | 241 | 5′-UTR | C → T | B.1 | |
| 3,037 | Nsp3 | C → T | B.1 | ||
| 9,347 | Nsp4 | A → G | T3028A | ||
| 14,408 | Nsp12 | C → T | P314L | B.1 | |
| 23,403 | S | A → G | D614G | B.1 | |
| 28,881 | N | G → A | R203K | B.1.1 | |
| 28,882 | N | G → A | B.1.1 | ||
| 28,883 | N | G → C | G204R | B.1.1 | |
| hCoV-19/Finland/4/2020 | 11,083 | Nsp6 | G → T | L3606F | B.2 |
| 14,805 | Nsp12 | C → T | |||
| 18,086 | Nsp14 | C → T | T1540I | ||
| 26,144 | Orf3a | G → T | G251V | ||
| 28,842 | N | G → T | I190S |
a
Nucleotide (nt) position is numbered according to the Wuhan-Hu-1 reference sequence.
b
5′-UTR, 5′-untranslated region; AA, amino acid; N, nucleoprotein; Nsp12, RNA-dependent RNA polymerase; S, spike protein; ORF3a, 3a open reading frame; Nsp14, 3′-5′ exonuclease.
c
Nsp3-Nsp4-Nsp6 form a complex, which is involved in viral replication.