TABLE 2.
Percent agreement and time to event outcomes
| Agreement with panel and culture | Proportion with 95% CI | P value |
|---|---|---|
| BCID | 98% (95–100%) | <0.0001a |
| BCID2 | 97% (93–99%) | |
| All cultures (n = 191) | Median hours (IQR) | |
| Time to BCID2 result | 19 (17–21) | |
| BCID time to optimal antimicrobial therapy | 35 (28–47) | 0.3c |
| BCID2 time to theoretical optimal therapyb | 26 (22–36) | |
| Enterococcus detected (n = 13) | Median hours (IQR) | |
| BCID time to optimal therapy | 51 (35–66) | 0.0046 |
| BCID2 time to theoretical optimal therapy | 17 (13–21) | |
| CTX-M resistance detected (n = 5)d | Median hours (IQR) | |
| BCID time to optimal therapye | 20 (11–77) | |
| BCID time to effective therapyf | 29 (16–40) | |
| BCID2 time to theoretical optimal therapy | 16 (13–18) |
a
Primary outcome was equivalence with an a priori margin of 10%; difference, 1.2% (95% CI, −0.8–3.1%); a P value of <0.05 indicates no significant difference in percentage agreement between the two panels.
b
Accounts for the reduction in time for Enterococcus faecalis and CTX-M.
c
Comparing the time to optimal therapy and time to theoretical optimal therapy for all cultures.
d
Data shown for descriptive purposes; no analysis performed.
e
n = 3 (two patients never received optimal therapy).
f
n = 4 (one patient never received effective therapy).