FIG 13.

Intestinal bacterial co-occurrence microbiome networks of the Ctca and Ppca groups. (A) Effects of single phages on bacterial co-occurrence networks. Bacterial co-occurrence networks associated with single-phase experiments. Each node represents a bacterial OTU, and each edge represents a negative (displayed in blue) or positive correlation (displayed in red). The node colors represent taxon classifications at the phylum level. (B) Based on a NetShift analysis of the Ctca and Ppca groups, the potential driver taxa are essential for observing the correlated network co-occurrence bacterial changes after phage treatment and are marked Ppca-Ctca. Each node size is proportional to its neighbor shift (NESH) score (a score identifying the importance of a given microbial taxon in the association network), and the nodes colored red are important driver taxa. As a result, the large red nodes represent driving taxa that are particularly important during phage infection. Line colors indicate node (taxa) connections: the association only appears in the case groups (red edge), the association only appears in the control group (green edge), and the association is in both the case groups and the control group (blue edge).