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Synergistic and additive effects of each antibiotic combination against CZA-susceptible and CZA-resistant P. aeruginosa isolatesa
| Antibiotic combination | % of isolates |
|||||
|---|---|---|---|---|---|---|
| CZA susceptible |
CZA resistant |
|||||
| Synergy | Additivity | Total | Synergy | Additivity | Total | |
| AMK+CZA | 8 | 3 | 78.6 | 5 | 1 | 85.7 |
| ATM+CZA | 2 | 4 | 42.9 | 4 | 2 | 85.7 |
| MEM+CZA | 1 | 1 | 14.3 | 2 | 0 | 28.6 |
| CST+CZA | 6 | 2 | 57.1 | 6 | 1 | 100.0 |
AMK, amikacin; ATM, aztreonam; MEM, meropenem; CST, colistin; CZA, ceftazidime-avibactam.
