Table 1.
Name | Name-function | Length (aa) | Name | Name-function | Length (aa) |
---|---|---|---|---|---|
ORF1ab | ORF1ab polyprotein | 7096 | nsp14 | 3′-to-5′ exonuclease, proof reading during RNA synthesis | 527 |
ORF1a | ORF1a polyprotein | 4405 | nsp15 | endoRNAse, cleaves RNA at polyuridylate sites | 346 |
nsp1 | leader protein, inhibits host protein translation | 180 | nsp16 | 2′-o-ribose methyltransferase, in RNA capping | 298 |
nsp2 | nsp2, disrupts host cell cycle | 638 | nsp11 | nsp11 | 13 |
nsp3 | Protease, lowers host immune response, and host translation | 1945 | S | Surface glycoprotein | 1273 |
nsp4 | nsp4 | 500 | ORF3a | ORF3a | 275 |
nsp5 | 3C-like proteinase | 306 | E | Envelope protein | 75 |
nsp6 | nsp6 | 290 | M | Membrane glycoprotein | 222 |
nsp7 | nsp7, primer synthesis and RNA replication | 83 | ORF6 | ORF6 | 61 |
nsp8 | nsp8, primer synthesis and RNA replication | 198 | ORF7a | ORF7a | 121 |
nsp9 | nsp9, interacts with DDX5 protein to facilitate replication of virus | 113 | ORF7b | ORF7b | 43 |
nsp10 | nsp10, mRNA cap methylation | 139 | ORF8 | ORF8 | 121 |
RdRp | RNA-dependent RNA polymerase, RNA replication | 932 | N | Nucleocapsid phosphoprotein | 419 |
nsp13 | Helicase, activity during RNA replication | 601 | ORF10 | ORF10 | 38 |
Adapted from Kadam et al. [64].