Figure 2.

Whole-brain FC analysis of the bilateral hippocampus in relapsing-remitting multiple sclerosis patients and healthy control subjects.

The left hippocampal regions with attenuated FC on the left and right side of the brain were the cingulate gyrus, limbic lobe, and right brain stem; while the regions with enhanced whole brain FC were the right cerebellum (posterior cerebellum), bilateral temporal lobe, suboccipital lobules, frontal lobe (prefrontal lobe, frontal gyrus), amygdala, lateral globus pallidus, and lentiform nucleus. The right hippocampal regions with attenuated FC on the left and right side of the brain were the right brain stem, limbic lobe, middle temporal gyrus, para-hippocampal gyrus, and left frontal lobe; while the regions with enhanced whole-brain FC were the right cerebellum (posterior cerebellum), left occipital lobe, left frontal lobe, insula, and parietal lobe. Red represents FC-enhanced regions and blue represents FC-attenuated regions. Independent two-sample t-tests were performed for the standardized FC (P < 0.001, corrected by AlphaSim, voxel > 5). Ordinate unit: T-value. FC: Functional connectivity.