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. 2021 Oct 28;17(11):e10396. doi: 10.15252/msb.202110396

Figure 4. Enrichment analysis for specific cellular pathways.

Figure 4

  • A
    KEGG pathway enrichment analysis of the virus–host PPI network was conducted, and RNA transport‐related proteins were highly enriched. The color of a node corresponds to the frequency of occurrence of the prey that has been detected in the virus–host interactome.
  • B
    In total, 693 proteins were connected by both viral baits and host–receptor baits in the combined interactome. KEGG pathway enrichment analysis of these 693 proteins was conducted, and three pathways, namely, RNA transportation, endocytosis, and protein processing in the ER, were highlighted.
  • C, D
    Enriched proteins were illustrated by the schematic diagram relevant to endocytosis (P‐value: 5.84 × 10−15) (C) and protein processing in ER (P‐value: 1.80 × 10−22) (D). The color of each slice in a node corresponds to the frequency of occurrence of the prey that was detected in virus–host interactome (left half slice) and host–receptor interactome (right half slice).