Study design and participation rates across assessment waves of the EPAD study. The Early Prediction of Adolescent Depression (EPAD) study took place over four assessment waves between April 2007 and September 2020 via interview and questionnaire. Numbers of participants reported are those participating at each wave via questionnaire, interview or both. Only 262 adults were contactable at wave 4. Reasons for this include loss of up to date contact details, withdrawal from the study, death and declining to participate due to ill health, bereavement or other commitments such as work (n=75). Of the 262 contactable participants at wave 4, 68 were unresponsive despite multiple communication attempts.