Table 2.

Association between adult ADHD symptoms (continuous and dichotomised) and clinical features of depression

Clinical feature of depression	Association with self-reported adult ADHD symptom score		Association with dichotomised self-reported adult ADHD symptoms (above clinical cut-point versus below)
	b or OR (95% CI)	p-value	b or OR (95% CI)	p-value
Depression age of onset of 25 or before	OR=1.45 (1.02, 2.05)	0.040	OR=2.09 (0.74, 5.88)	0.163
Ever had GAF score ≤ 50 (Severe impairment associated with depression)	OR=1.73 (1.08, 2.75)	0.021	- -	- - -
Number of MDD episodes during study	b=0.74 (0.51, 0.98)	<0.001	b=1.93 (1.17, 2.69)	<0.001
Subthreshold depression persistence	b=0.22 (0.01, 0.43)	0.044	b=0.29 (-0.368, 0.948)	0.385
Ever hospitalised	OR=1.94 (1.29, 2.91)	0.001	OR=4.58 (1.58, 13.25)	0.005
Use of non-first-line antidepressants	OR=2.04 (1.35, 3.09)	0.001	OR=5.85 (1.99, 17.23)	0.001
Ever attempted self-harm or suicide during study	OR=3.46 (1.46, 8.21)	0.005	- - -	- - -
Ever had psychotic affective symptoms during study	OR=0.89 (0.56, 1.40)	0.603	OR=0.92 (0.22, 3.98)	0.916
Irritability score	b=1.54 (1.18, 1.90)	<0.001	b=3.55 (2.32, 4.78)	<0.001

Results in complete case women are shown (n=148). ADHD symptoms were dichotomised using the clinical cut point of the Adult ADHD Investigator Symptom Rating Scale AISRS (≥24). All participants above the cut point for ADHD had had a GAF score below 50, so the association of dichotomised ADHD and depression impairment could not be tested due to complete separation issues. The association between dichotomised ADHD and suicide or self-harm attempts could not be tested due to small cell sizes. ADHD attention-deficit/hyperactivity disorder, MDD major depressive disorder, GAF Global Assessment of Functioning, b unstandardized beta, CI confidence interval, OR odds ratio