. Author manuscript; available in PMC: 2021 Nov 15.

Published in final edited form as: Cancer. 2020 Sep 1;126(22):4936–4947. doi: 10.1002/cncr.33145

Table 3:

Effect of ADA on LMB-100 blood levels

	Patient ID⁺	LMB-100 Dose (mcg/kg)	Cycle 1		Cycle 2		Cycle 3		Cycle 4

			ADA^a	C_max^b (ng/ml)	ADA^a	C_max^b (ng/ml)	ADA^a	C_max^b (ng/ml)	ADA^a	C_max^b (ng/ml)

Multicenter Phase I	1	45	0.436	620	2.996	2.1	^-	^-	^-	^-
	2	65	0.025	1150	0.727	711	^-	^-	^-	^-
	3	100	0.848	495	3.094	2.1	^-	^-	^-	^-
	4	100	0.02	1790	0.024	1610	2.431	267	3.331	^-
	5	100	0.025	1650	0.052	1360	2.418	2.1	3.44	^-
	6	170	0.037	3040	0.02	1940	^-	^-	^-	^-
	7	170	0.028	3430	3.308	527	^-	^-	^-	^-
	8	170	0.024	1930	0.227	1550	^-	^-	^-	^-
	9	170	0.024	2760	0.105	3950	0.292	3490	1.604	2.1
	12	250	0.387	2960	3.286	^-	^-	^-	^-	^-
	13	250	0.02	5480	0.049	4770	^-	^-	^-	^-
	14	250	0.019	4340	^-	^-	^-	^-	^-	^-
	15	250	0.454	3730	3.232	2.1	^-	^-	^-	^-
NCI Phase I	16	170	0.007	1991	1.846	1091	2.67	2.1	2.663	2.1
	17	170	0.057	2286	2.466	297	2.69	70	2.681	2.1
	18	170	0.392	2760	2.721	4.4	2.619	2.1	2.661	2.1
	19	140	0.05	1054	0.164	681	2.758	2.1	2.744	2.1
	20	140	0.446	1124	^x	2.1	^-	^-	^-	^-
	21	140	0.027	3118	2.31	2450	3.389	2.1	3.277	2.1
	22	140	0.007	2584	2.394	1099	3.432	2.1	3.433	2.1
	23	140	0.012	1721	3.236	2.1	3.562	2.1	3.743	2.1
	24	140	0.174	1526	3.598	27.8	3.623	20	3.639	2.1
	25	140	1.476	2689	2.863	5.1	2.967	^-	2.979	^-

⁺

Two patients who received only a single dose of LMB-100 at 200 mcg/kg are not included

Anti-LMB-100 antibodies (ADA) were measured prior to infusion

LMB-100 blood levels

ADA assay not performed

Patients did not receive the 2^nd, 3^rd or 4^th cycle of LMB-100