TABLE 2.
Properties of S. pneumoniae isolates from patients with meningitisa
ST | Strain no. | Allelic profile
|
Serotype | Yr of isolation | MIC (μg/ml) of:
|
Comments | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
aroE | gdh | gki | recP | spi | xpt | ddl | Pen | Ery | Tet | Cm | Ctx | |||||
156 | MA9754 | 7 | 11 | 10 | 1 | 6 | 8 | 1 | 9V | 1997 | 2 | 0.25 | 0.5 | 2 | 1 | France9V-3 clone |
156 | MA9883 | 7 | 11 | 10 | 1 | 6 | 8 | 1 | 9V | 1998 | 1 | 0.06 | 0.25 | 2 | 0.5 | France9V-3 clone |
156 | MA9892 | 7 | 11 | 10 | 1 | 6 | 8 | 1 | 9V | 1998 | 1 | 0.06 | 0.25 | 2 | 0.5 | France9V-3 clone |
156 | MA98111 | 7 | 11 | 10 | 1 | 6 | 8 | 1 | 9V | 1998 | 1 | 0.12 | 0.25 | 2 | 0.5 | France9V-3 clone |
156 | MA9717 | 7 | 11 | 10 | 1 | 6 | 8 | 1 | 14 | 1997 | 1 | 0.06 | 0.25 | 2 | 0.25 | France9V-3 clone |
156 | MA9735 | 7 | 11 | 10 | 1 | 6 | 8 | 1 | 14 | 1997 | 0.5 | 0.12 | 0.5 | 2 | 0.5 | France9V-3 clone |
156 | MA9756 | 7 | 11 | 10 | 1 | 6 | 8 | 1 | 14 | 1997 | 1 | 0.12 | 0.5 | 2 | 0.5 | France9V-3 clone |
44 | MA9747 | 1 | 11 | 10 | 1 | 6 | 8 | 1 | 14 | 1997 | 2 | 0.12 | 0.5 | 2 | 1 | Single-locus variant of the France9V-3 clone |
144 | MA98100 | 7 | 5 | 10 | 1 | 6 | 8 | 1 | 14 | 1998 | 2 | 0.06 | 0.25 | 2 | 4 | Single-locus variant of the France9V-3 clone |
167 | MA9720 | 7 | 11 | 10 | 1 | 4 | 8 | 1 | 14 | 1997 | 0.5 | 0.06 | 0.25 | 2 | 0.25 | Single-locus variant of the France9V-3 clone |
265 | MA98114 | 7 | 34 | 10 | 1 | 6 | 8 | 1 | 14 | 1998 | 1 | 0.12 | 0.25 | 2 | 0.5 | Single-locus variant of the France9V-3 clone |
90 | MA9714 | 5 | 6 | 1 | 2 | 6 | 3 | 4 | 6B | 1997 | 0.5 | 128 | 16 | 16 | 0.25 | Spain6B-2 clone |
90 | MA9716 | 5 | 6 | 1 | 2 | 6 | 3 | 4 | 6B | 1997 | 0.5 | 0.5 | 16 | 2 | 0.25 | Spain6B-2 clone |
90 | MA9733 | 5 | 6 | 1 | 2 | 6 | 3 | 4 | 6B | 1997 | 1 | 8 | 64 | 2 | 0.5 | Spain6B-2 clone |
90 | MA9888 | 5 | 6 | 1 | 2 | 6 | 3 | 4 | 6B | 1998 | 1 | 128 | 32 | 8 | 0.5 | Spain6B-2 clone |
93 | MA9877 | 5 | 6 | 1 | 15 | 6 | 3 | 4 | 6B | 1998 | 1 | 128 | 64 | 16 | 0.5 | Single-locus variant of the Spain6B-2 clone |
93 | MA9880 | 5 | 6 | 1 | 15 | 6 | 3 | 4 | 6B | 1998 | 1 | 128 | 32 | 16 | 0.5 | Single-locus variant of the Spain6B-2 clone |
94 | MA9896 | 5 | 6 | 1 | 2 | 6 | 3 | 54 | 6B | 1998 | 2 | 128 | 64 | 16 | 1 | Single-locus variant of the Spain6B-2 clone |
81 | MA9725 | 4 | 4 | 2 | 4 | 4 | 1 | 1 | 19F | 1997 | 1 | 128 | 32 | 16 | 0.5 | Spain23F-1 clone |
81 | MA98113 | 4 | 4 | 2 | 4 | 4 | 1 | 1 | 23F | 1998 | 2 | 0.12 | 16 | 16 | 2 | Spain23F-1 clone |
81 | MA9868 | 4 | 4 | 2 | 4 | 4 | 1 | 1 | 23F | 1998 | 1 | 0.12 | 32 | 16 | 0.5 | Spain23F-1 clone |
81 | MA9879 | 4 | 4 | 2 | 4 | 4 | 1 | 1 | 23F | 1998 | 2 | 8 | 32 | 16 | 1 | Spain23F-1 clone |
85 | MA98102 | 4 | 4 | 2 | 4 | 4 | 1 | 47 | 23F | 1998 | 2 | 0.06 | 1 | 16 | 1 | Single-locus variant of the Spain23F clone |
85 | MA98118 | 4 | 4 | 2 | 4 | 4 | 1 | 47 | 23F | 1998 | 1 | 0.06 | 32 | 16 | 1 | Single-locus variant of the Spain23F clone |
189 | MA9887 | 8 | 4 | 2 | 4 | 4 | 1 | 1 | 23F | 1998 | 1 | 0.06 | 16 | 8 | 1 | Single-locus variant of the Spain23F clone |
260 | MA9737 | 26 | 9 | 15 | 14 | 9 | 16 | 19 | 3 | 1997 | 0.015 | 4 | 0.5 | 2 | 0.015 | |
260 | MA9753 | 26 | 9 | 15 | 14 | 9 | 16 | 19 | 3 | 1997 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
260 | MA9866 | 26 | 9 | 15 | 14 | 9 | 16 | 19 | 3 | 1998 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
260 | MA9870 | 26 | 9 | 15 | 14 | 9 | 16 | 19 | 3 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
260 | MA9881 | 26 | 9 | 15 | 14 | 9 | 16 | 19 | 3 | 1998 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
260 | MA9890 | 26 | 9 | 15 | 14 | 9 | 16 | 19 | 3 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
113 | MA979 | 7 | 2 | 1 | 1 | 10 | 1 | 21 | 18C | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
113 | MA9863 | 7 | 2 | 1 | 1 | 10 | 1 | 21 | 18C | 1998 | 0.015 | 0.12 | 0.5 | 2 | 0.015 | |
113 | MA9889 | 7 | 2 | 1 | 1 | 10 | 1 | 21 | 18C | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
110 | MA9727 | 7 | 2 | 1 | 5 | 10 | 1 | 21 | 18C | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
122 | MA9721 | 7 | 2 | 29 | 1 | 10 | 1 | 21 | 18C | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
262 | MA9893 | 28 | 2 | 1 | 1 | 10 | 1 | 21 | 18C | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
218 | MA9719 | 10 | 20 | 14 | 1 | 6 | 1 | 29 | 12F | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
218 | MA9724 | 10 | 20 | 14 | 1 | 6 | 1 | 29 | 12F | 1997 | 0.015 | 0.12 | 0.5 | 2 | 0.015 | |
218 | MA98105 | 10 | 20 | 14 | 1 | 6 | 1 | 29 | 12F | 1998 | 0.015 | 0.06 | 0.5 | 4 | 0.015 | |
218 | MA9876 | 10 | 20 | 14 | 1 | 6 | 1 | 29 | 12F | 1998 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
135 | MA9732 | 7 | 5 | 4 | 12 | 6 | 20 | 46 | 6B | 1997 | 0.12 | 0.06 | 0.5 | 2 | 0.12 | |
135 | MA9743 | 7 | 5 | 4 | 12 | 6 | 20 | 46 | 6B | 1997 | 0.12 | 128 | 4 | 4 | 0.06 | |
135 | MA9744 | 7 | 5 | 4 | 12 | 6 | 20 | 46 | 6B | 1997 | 0.12 | 128 | 8 | 4 | 0.12 | |
136 | MA9882 | 7 | 5 | 4 | 1 | 6 | 20 | 46 | 6B | 1998 | 0.25 | 64 | 64 | 16 | 0.25 | |
53 | MA98103 | 2 | 5 | 1 | 11 | 16 | 3 | 14 | 8 | 1998 | 0.015 | 128 | 0.5 | 2 | 0.015 | |
53 | MA9862 | 2 | 5 | 1 | 11 | 16 | 3 | 14 | 8 | 1998 | 0.015 | 0.25 | 0.25 | 1 | 0.015 | |
53 | MA9864 | 2 | 5 | 1 | 11 | 16 | 3 | 14 | 8 | 1998 | 0.015 | 0.12 | 16 | 4 | 0.015 | |
56 | MA9875 | 2 | 5 | 1 | 11 | 16 | 44 | 14 | 8 | 1998 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
202 | MA9729 | 8 | 16 | 19 | 15 | 6 | 40 | 26 | 19A | 1997 | 0.015 | 128 | 32 | 16 | 0.03 | |
202 | MA9742 | 8 | 16 | 19 | 15 | 6 | 40 | 26 | 19A | 1997 | 0.015 | 128 | 64 | 4 | 0.015 | |
202 | MA9861 | 8 | 16 | 19 | 15 | 6 | 40 | 26 | 19A | 1998 | 0.015 | 0.25 | 64 | 1 | 0.015 | |
196 | MA9895 | 8 | 11 | 19 | 15 | 6 | 40 | 26 | 19A | 1998 | 0.5 | 128 | 32 | 4 | 0.5 | |
100 | MA971 | 5 | 12 | 29 | 12 | 9 | 39 | 18 | 33F | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
100 | MA9869 | 5 | 12 | 29 | 12 | 9 | 39 | 18 | 33F | 1998 | 0.03 | 0.12 | 0.25 | 4 | 0.015 | |
100 | MA9873 | 5 | 12 | 29 | 12 | 9 | 39 | 18 | 33F | 1998 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
101 | MA9734 | 5 | 13 | 1 | 1 | 6 | 41 | 18 | 15B | 1997 | 0.015 | 0.12 | 0.5 | 2 | 0.015 | |
101 | MA9867 | 5 | 13 | 1 | 1 | 6 | 41 | 18 | 15B | 1998 | 0.03 | 0.12 | 0.5 | 4 | 0.015 | |
101 | MA98112 | 5 | 13 | 1 | 1 | 6 | 41 | 18 | 15C | 1998 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
180 | MA977 | 7 | 15 | 2 | 10 | 6 | 1 | 22 | 3 | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
180 | MA9878 | 7 | 15 | 2 | 10 | 6 | 1 | 22 | 3 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
180 | MA9885 | 7 | 15 | 2 | 10 | 6 | 1 | 22 | 3 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
177 | MA9711 | 7 | 14 | 4 | 12 | 1 | 1 | 14 | 19F | 1997 | 0.03 | 0.06 | 64 | 2 | 0.03 | |
177 | MA9723 | 7 | 14 | 4 | 12 | 1 | 1 | 14 | 19F | 1997 | 0.03 | 0.06 | 8 | 2 | 0.03 | |
179 | MA9874 | 7 | 14 | 40 | 12 | 1 | 1 | 14 | 19F | 1998 | 0.03 | 128 | 64 | 4 | 0.03 | |
62 | MA9728 | 2 | 5 | 29 | 12 | 16 | 3 | 14 | 11A | 1997 | 0.03 | 0.06 | 0.25 | 2 | 0.015 | |
62 | MA9751 | 2 | 5 | 29 | 12 | 16 | 3 | 14 | 11A | 1997 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
55 | MA9750 | 2 | 5 | 1 | 12 | 16 | 3 | 14 | 11A | 1997 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
88 | MA974 | 5 | 5 | 7 | 7 | 8 | 5 | 7 | 19F | 1997 | 0.12 | 0.06 | 32 | 8 | 0.12 | Minor penicillin-resistant serotype 19F clone |
89 | MA9748 | 5 | 5 | 7 | 7 | 8 | 5 | 1 | 19F | 1997 | 0.5 | 0.06 | 64 | 2 | 0.25 | Minor penicillin-resistant serotype 19F clone |
106 | MA9897 | 5 | 16 | 7 | 7 | 8 | 5 | 7 | 19F | 1998 | 0.25 | 128 | 32 | 16 | 0.25 | Minor penicillin-resistant serotype 19F clone |
30 | MA9710 | 1 | 5 | 27 | 20 | 1 | 1 | 1 | 16F | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
30 | MA9749 | 1 | 5 | 27 | 20 | 1 | 1 | 1 | 16F | 1997 | 0.015 | 0.12 | 0.25 | 2 | 0.015 | |
63 | MA9718 | 2 | 5 | 36 | 12 | 17 | 21 | 14 | 15A | 1997 | 0.12 | 128 | 64 | 2 | 0.06 | |
63 | MA9757 | 2 | 5 | 36 | 12 | 17 | 21 | 14 | 15A | 1997 | 0.12 | 128 | 64 | 4 | 0.06 | |
133 | MA9726 | 7 | 5 | 1 | 1 | 10 | 1 | 45 | 18C | 1997 | 0.015 | 0.12 | 0.5 | 2 | 0.015 | |
133 | MA9730 | 7 | 5 | 1 | 1 | 10 | 1 | 45 | 18C | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
247 | MA9738 | 16 | 13 | 4 | 5 | 6 | 10 | 14 | 4 | 1997 | 0.015 | 0.06 | 0.5 | 4 | 0.015 | |
248 | MA9736 | 16 | 13 | 4 | 5 | 6 | 39 | 14 | 4 | 1997 | 0.015 | 0.06 | 0.5 | 2 | 0.015 | |
42 | MA9758 | 1 | 8 | 9 | 9 | 6 | 4 | 6 | 23A | 1997 | 0.015 | 0.06 | 64 | 16 | 0.015 | |
264 | MA98110 | 1 | 33 | 9 | 9 | 6 | 4 | 6 | 23A | 1998 | 0.015 | 0.12 | 32 | 8 | 0.015 | |
17 | MA9745 | 1 | 5 | 4 | 11 | 9 | 3 | 47 | 14 | 1997 | 1 | 128 | 32 | 16 | 0.5 | Single-locus variant of the Spain14-5 clone |
23 | MA9860 | 1 | 5 | 4 | 5 | 35 | 3 | 8 | 14 | 1998 | 1 | 128 | 0.25 | 2 | 0.5 | |
32 | MA9891 | 1 | 6 | 4 | 5 | 15 | 1 | 20 | 10F | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
45 | MA9741 | 1 | 12 | 1 | 23 | 15 | 26 | 14 | 18C | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
64 | MA9898 | 2 | 6 | 6 | 12 | 16 | 3 | 14 | 11A | 1998 | 0.015 | 0.12 | 0.5 | 4 | 0.015 | |
69 | MA9739 | 2 | 8 | 37 | 4 | 6 | 1 | 1 | 9N | 1997 | 0.015 | 0.06 | 0.5 | 2 | 0.015 | |
70 | MA9872 | 2 | 13 | 1 | 4 | 6 | 12 | 1 | 13 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
72 | MA9752 | 2 | 13 | 2 | 4 | 9 | 4 | 1 | 24F | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
97 | MA9740 | 5 | 7 | 4 | 2 | 10 | 1 | 27 | 10A | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
103 | MA9759 | 5 | 13 | 38 | 1 | 6 | 1 | 18 | 15B | 1997 | 0.06 | 0.12 | 0.25 | 2 | 0.06 | |
104 | MA9894 | 5 | 13 | 41 | 2 | 6 | 3 | 4 | 6B | 1998 | 0.5 | 128 | 64 | 16 | 0.25 | |
105 | MA98101 | 5 | 15 | 4 | 1 | 6 | 1 | 6 | 25 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
123 | MA9884 | 7 | 2 | 40 | 1 | 10 | 1 | 45 | 17F | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
142 | MA9899 | 7 | 5 | 8 | 6 | 6 | 12 | 8 | 23F | 1998 | 0.5 | 0.12 | 0.5 | 2 | 0.12 | |
216 | MA9871 | 10 | 16 | 32 | 1 | 15 | 1 | 6 | 20 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
224 | MA975 | 10 | 25 | 8 | 6 | 25 | 6 | 8 | 6A | 1997 | 0.06 | 0.06 | 0.25 | 2 | 0.06 | |
225 | MA9755 | 10 | 32 | 6 | 24 | 33 | 28 | 18 | 28A | 1997 | 0.015 | 0.12 | 0.5 | 4 | 0.015 | |
228 | MA9886 | 12 | 8 | 1 | 5 | 17 | 4 | 20 | 1 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
229 | MA9865 | 12 | 13 | 1 | 5 | 6 | 1 | 53 | 15B | 1998 | 2 | 128 | 64 | 2 | 1 | |
235 | MA9731 | 15 | 8 | 8 | 18 | 15 | 1 | 31 | 20 | 1997 | 0.015 | 0.06 | 32 | 16 | 0.015 | |
241 | MA9712 | 25 | 31 | 4 | 16 | 32 | 28 | 44 | 18A | 1997 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
244 | MA98104 | 16 | 2 | 4 | 1 | 6 | 10 | 18 | 4 | 1998 | 0.015 | 0.06 | 0.25 | 2 | 0.015 | |
259 | MA976 | 24 | 5 | 35 | 1 | 15 | 12 | 43 | 4 | 1997 | 0.015 | 0.06 | 0.5 | 4 | 0.015 | |
263 | MA98109 | 2 | 11 | 2 | 1 | 17 | 1 | 1 | 20 | 1998 | 0.015 | 0.25 | 0.25 | 2 | 0.015 | |
266 | MA98116 | 16 | 35 | 1 | 16 | 9 | 45 | 17 | 28 | 1998 | 0.015 | 0.06 | 0.5 | 4 | 0.015 |
Isolates are grouped into STs, which have identical allelic profiles, and clones, which also include isolates that differ at a single locus. Pen, penicillin; Ery, erythromycin; Tet, tetracycline; Cm, chloramphenicol; Ctx, cefotaxime.