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. Author manuscript; available in PMC: 2022 Jan 8.
Published in final edited form as: Nat Aging. 2021 Jul 8;1(7):585–597. doi: 10.1038/s43587-021-00072-0

Fig. 7 |. Glial AP1 promotes early TBI recovery but chronically drives tauopathy.

Fig. 7 |

Left, simplified fly brain schematic showing an intracortical synapse surrounded by a resting state glial cell. Middle, in the early post-injury period (<3 dpi), ERK activates glial AP1, which orchestrates a gene program vital to injury recovery. Right, sustained AP1 activity fosters a prodegenerative glial state that promotes human tau pathology. Solid lines are known interactions; dashed lines are proposed interactions.