Fig 1. CACAO competitors contribute a large number of GO annotations.

Overall CACAO contributions are summarized in the context of the workflow for quality control and submission to the GO Consortium. CACAO users consume the primary literature, collect information about normal gene functions from the paper study subjects, and capture the evidence and conclusions using the GO. Those annotations are reviewed by trained judges and marked as unacceptable (red X), requiring changes (yellow!, or purple? flagged for further review), or acceptable (green check, or blue check after correction) within the GONUTS framework. Competitors challenge entries and engage in peer review until an annotation is corrected or marked unacceptable. Fully vetted annotations are deposited into the public GO database maintained by professional biocurators and used by scientists worldwide. As required, CACAO-submitted annotations will be updated to reflect rearrangements and changes in GO. CACAO, Community Assessment of Community Annotation with Ontologies; GO, Gene Ontology; GONUTS, Gene Ontology Normal Usage Tracking System.