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. 2021 Oct 28;16(10):e0259133. doi: 10.1371/journal.pone.0259133

Fig 2. Prophylactic or rescue dosing of RLS-0071 reduces acute lung injury.

Fig 2

Representative histology (H&E stain) of rat lungs. (A) sham control, (B) first hit only, (C) 2-hit, (D) 2-hit + 10 mg/kg prophylactic dose RLS-0071, (E) 2-hit + 40 mg/kg prophylactic dose RLS-0071, (F) 2-hit + 160 mg/kg prophylactic dose RLS-0071, (G) 2-hit + 40 mg/kg rescue dose RLS-0071 at 0.5 min, (H) 2-hit + 40 mg/kg rescue dose RLS-0071 at 60 min, (I) 2-hit + 40 mg/kg rescue dose RLS-0071 at 90 min, (J) 2-hit + 40 mg/kg rescue dose RLS-0071 at 120 min and (K) 2-hit + 40 mg/kg rescue dose RLS-0071 at 180 min. Bar represents 100 μm. Tissues were observed with a microscope (BX50, Olympus) at a magnification of 20X at room temperature. Images were acquired with a digital camera (DP70, Olympus).