Skip to main content
. 2021 Oct 28;16(10):e0259133. doi: 10.1371/journal.pone.0259133

Fig 6. RLS-0071 reduces levels of inflammatory cytokines in the blood.

Fig 6

Cytokine levels (A) IL-1a, (B) IL-1b, (C) IL-6, (D) IFN-g, (E) IL-17, (F) IL-18, (G) TNFa and (H) RANTES from terminal blood draws were determined by xMAP bead based immunoassay for the following experimental groups: sham, 2-hit, 2-hit + 10mg/kg prophylactic dose RLS-0071, 2-hit + 160mg/kg prophylactic dose RLS-0071 as well as 2-hit + 40mg/kg rescue dose RLS-0071 and 2-hit + 160mg/kg rescue dose RLS-0071. For sake of clarity only rescue dosing data is shown. Data are means and standard error of the mean. * denotes P <0.05 compared to animals receiving the 2 hit insult.