TABLE 2.

Characteristics of patients with proven invasive aspergillosis^a

Patient no.	Sex/age (yr)	Neutropenia (days)	Steroidsb	No. of pos. samples/total no. of samples	Time between first pos. test and clinical suspicionc	Underlying disorder or condition(s)	Site(s) of Aspergillus isolation	Fungal infection site at autopsy
1	Fe/42	6	−	9/12	+3	Relapsed ALL	Sputum, BAL, autopsy specimen lung	Right lung, myocardium, thyroid gland
2	Ma/10	18	+	8/12	−7	Relapsed ALL, alloBMT, GVHD	Autopsy specimen lung	Lung bilateral
3	Fe/43	10	+	2/5	−3	Relapsed NHL	Autopsy specimen lung	Lung bilateral, myocardium, liver
4	Ma/61	4	+	1/2	−2	NHL	Autopsy specimen lung	Right lung upper lobe
5	Ma/41	19	+	20/20	−3	MDS, alloBMT, GVHD	Sputum, BAL, autopsy specimen lung	Lung bilateral
6	Ma/54	18	+	5/7	0	Relapsed NHL	Sputum, BAL, autopsy specimen lung	Lung bilateral, myocardium, pericardium, stomach, thyroid gland
7	Fe/70	54	−	2/2	−3	HCL	Sputum	Lung bilateral, liver
8	Ma/38	6	+	5/9	−15	AML, alloBMT, GVHD	Sputum, BAL, autopsy specimen lung	Lung bilateral
9	Fe/16	>82	−	6/10	−12	Relapsed AML	Autopsy specimen lung	Lung bilateral, pericardium
10	Ma/33	3	+	17/18	−22	NHL post-liver Tx	Autopsy specimen Pericardium	Left lung, pleura, myocardium, Pericardium, kidney, thyroid gland
11	Ma/35	0	+	11/25	−13	ALL, alloBMT, GVHD	Sputum, BAL	Cerebral, lung bilateral
12	Ma/2.5	20	−	9/11	+4	AML, alloBMT	Autopsy specimen lung	Lung bilateral
13	Ma/53	24	+	7/12	−23	NHL-CLL	Autopsy specimen lung	Lung bilateral
14	Ma/72	>18	−	5/6	+6	AML	Autopsy specimen lung	Lung bilateral
15	Fe/65	22	−	3/7	+6	AML	BAL	Lung bilateral
16	Ma/71	12	−	2/3	−1	sAA	Autopsy specimen lung	Right lung and pancreas
17	Fe/13	>40	−	3/11	+2	Relapsed AML	Sputum, BAL	Lung bilateral
18	Ma/35	0	+	14/26	−22	AML, alloBMT, GVHD	Sputum, BAL, autopsy specimen lung	Cerebral
19	Ma/52	79	+	2/18	−6	Relapsed ALL	Autopsy specimen lung	Lung bilateral
20	Ma/62	23	+	0/5	NA	NHL-CLL	Sputum, BAL	Bronchus biopsy
21	Ma/69	>180	−	0/9	NA	HCL	Sputum, BAL, autopsy specimen	Lung bilateral, trachea
22	Ma/64	>40	−	5/7	−2	AML	Autopsy specimen	Lung bilateral, trachea
23	Fe/67	>60	+	3/3	−8	AML	Sputum, autopsy specimen	Left lung upper lobe
24	Ma/45	9	+	2/4	−6	Relapsed myeloma	Autopsy specimen lung	Lung bilateral
25	Ma/57	19	−	6/9	+4	Relapsed AML	Autopsy specimen lung	Lung bilateral
26	Ma/69	24	−	8/10	−5	Refractory AML	Autopsy specimen lung	Lung bilateral
27	Ma/53	0	+	13/13	−6	Relapsed NHL	Sputum, BAL, autopsy specimen lung	Lung, pleura, thyroid gland

^aAML, acute myeloid leukemia; ALL, acute lymphocytic leukemia; CML, chronic myeloid leukemia; sAA, severe aplastic anemia; MDS, myelodysplastic syndrome; NHL, non-Hodgkin’s lymphoma; HCL, hairy cell leukemia; AlloBMT, allogeneic bone marrow transplantation; GVHD, graft-versus-host disease; Tx, transplantation; BAL, bronchoalveolar lavage; Ma, male; Fe, female; NA, not applicable; pos, positive. 

^b+, present; −, absent. 

^cValues are numbers of days elapsed between first positive test result and clinical suspicion of IA. Negative numbers indicate the number of days ELISA results were positive before clinical suspicion.