Table 2.

Group analysis of regional GM volume and perfusion abnormalities in RRMS-IC group compared to control subjects

Brain region	X,Y,Z (mm)	Number of voxels	T - Value
MRI
Left inferior frontal gyrus	−38, 12,–16	61	5.85
Right insula	44, 2,–6	81	6.73
Left insula	-42,–10, 4	17	4.22
Left precentral gyrus	−46, 0, 10	8	3.99
pSPECT
Right parahippocampal gyrus, right hippocampus, right amygdala, right fusiform gyrus	38,2,–20	251	8.25
Left gyrus rectus, right gyrus rectus, right middle frontal gyrus, left middle frontal gyrus, left superior frontal gyrus, right inferior frontal gyrus, right superior frontal gyrus	−4, 38,–20	340	6.57
Right inferior parietal lobule, right superior parietal lobule, right postcentral gyrus, right angular gyrus	50,–50, 54	238	5.72
Left inferior parietal lobule, left postcentral gyrus, left angular gyrus	-54,–42, 54	190	5.3
Right precentral gyrus, right superior frontal gyrus, left precentral gyrus, left paracentral lobule	20,–10, 76	365	5.24
Right middle temporal gyrus	60,–26, −14	27	4.89
Left inferior temporal gyrus	-52,–30, −24	7	4.51
Left crus I of cerebellar hemisphere	-36,–76, −26	7	4.46
Right middle temporal gyrus	64,–12, −14	3	4.38
Left inferior temporal gyrus, left middle temporal gyrus	-60,–22, −20	6	4.3
Left crus I of cerebellar hemisphere	-32,–78, −26	1	3.99
Right postcentral gyrus	48,–30, 62	2	3.69
Left inferior frontal gyrus	−54, 18,–2	1	3.62
Left postcentral gyrus	-34,–32, 68	1	3.39
Right postcentral gyrus	38,–42, 62	1	3.38

GM, gray matter; RRMS-IC, Relapsing-Remitting Multiple Sclerosis with Intact Cognition; SPECT, single photon emission tomography.