Table 2.

CIBERSORTx analyses of immune cells. P values for absolute and fractional abundance are shown for 22 cell types using B-mode (batch correction) as applied to the normalized bulk RNA-seq gene expression dataset. Bolded p values (p < 0.05) are significant in the indicated subtypes. P values were calculated by a two-sided Wilcoxon rank-sum test.

Cell type	Absolute abundance	Fractional abundance
Naïve B-cells	0.059	0.017 (WT)
Memory B-cells	0.22	0.43
Plasma cells	0.8	0.68
CD8 T-cells	0.91	0.87
CD4 naïve T-cells	0.65	0.92
CD4 memory resting T-cells	0.85	0.84
CD4 memory activated T-cells	0.023 (K27M)	0.096
Follicular helper T-cells	0.08	0.012 (WT)
Regulatory T-cells	0.4	0.21
Gamma-delta T-cells	0.81	0.77
Resting NK cells	0.042 (K27M)	0.3
Activated NK cells	0.13	0.13
Monocytes	0.77	0.88
M0 macrophages	0.099	0.21
M1 macrophages	0.21	0.084
M2 macrophages	0.21	0.032 (WT)
Resting DCs	0.3	0.15
Activated DCs	0.0041 (K27M)	0.0081 (K27M)
Resting mast cells	0.54	0.82
Activated mast cells	0.04 (WT)	0.018 (WT)
Eosinophils	0.018 (K27M)	0.063
Neutrophils	0.013 (K27M)	0.03 (K27M)