FIGURE 1.

Melatonin reduces infarct volume and improves motor functions after ischemic injury. (a) Timeline of procedures for treatments in rats. (b) Representative Fluoro‐Jade B staining in coronal sections of rats at day 10 after MCAO. The bright green areas indicate infarct areas. (c) Melatonin significantly reduced both the infarct volume and the length of the degenerated contralateral corpus callosum of ischemic injured rats at day 10 after MCAO (n = 6). (d) The wire test and cylinder test revealed that the latency to fall and the use of impaired forelimbs, respectively, in melatonin‐treated rats were significantly increased compared to those of the vehicle‐treated group at day 10 after MCAO (n = 12). Data are presented as the mean ± SE, n = 6−12. *p < 0.05, assessed by two‐tailed unpaired Student's t‐test