TABLE 2.
Astrocytic gene signatures are enriched relative to other cell types in hPDGFRA KI mice
| Astrocyte vs. | Size | ES | NES | NOM p‐val | FDR q‐val | FWER p‐val |
|---|---|---|---|---|---|---|
| Newly formed OL | 462 | 0.266086 | 6.631515 | 0 | 0 | 0 |
| Myelinating OL | 453 | 0.224306 | 5.620024 | 0 | 0 | 0 |
| OPC | 460 | 0.22091 | 5.39882 | 0 | 0 | 0 |
| Neuron | 466 | 0.251861 | 6.300609 | 0 | 0 | 0 |
| Microglia | 466 | 0.202658 | 5.059472 | 0 | 0 | 0 |
| Endothelial | 453 | 0.201959 | 4.962529 | 0 | 0 | 0 |
Abbreviations: ES, enrichment score; FDR, false discovery rate; FWER, family wise error rate; NES, normalized enrichment score; NOM, nominal.
RNA‐seq data from BS of P18/P19 Olig2‐Cre; p53fl/fl; PDGFRAfl/+ (n = 4) and Olig2‐Cre; p53fl/fl (n = 4) mice. “0” indicates value <.01.