TABLE 3.
Expression of OL markers in hPDGFRA KI mice with no p53 loss
| Brainstem | Spinal cord | |||||
|---|---|---|---|---|---|---|
| Age | Ctrl | KI | p‐Value | Ctrl | KI | p‐Value |
| MBP | ||||||
| P0 | 0.0202 ± 0.0029 (n = 10) | 0.0257 ± 0.0037 (n = 6) | .2598 | 0.0013 ± 0.0003 (n = 8) | 0.0017 ± 0.0008 (n = 7) | .6447 |
| P10 | 0.0541 ± 0.0064 (n = 9) | 0.0408 ± 0.0035 (n = 7) | .1149 | 0.0171 ± 0.0028 (n = 9) | 0.0195 ± 0.0034 (n = 8) | .5707 |
| P19 | 0.1734 ± 0.0112 (n = 3) | 0.0751 ± 0.0049 (n = 11) | 2.4852 e‐06 | 0.1968 ± 0.0175 (n = 3) | 0.0520 ± 0.0069 (n = 7) | 2.9716 e‐05 |
| CNPase | ||||||
| P0 | 0.0362 ± 0.0026 (n = 10) | 0.0327 ± 0.0031 (n = 6) | .4148 | 0.0133 ± 0.0013 (n = 3) | 0.0129 ± 0.006 (n = 4) | .7476 |
| P10 | 0.0506 ± 0.0085 (n = 9) | 0.0391 ± 0.0037 (n = 7) | .2830 | 0.0873 ± 0.0123 (n = 8) | 0.0469 ± 0.0062 (n = 8) | .0110 |
| P19 | 0.1379 ± 0.0033 (n = 3) | 0.0546 ± 0.0044 (n = 11) | .0091 | 0.1929 ± 0.0117 (n = 3) | 0.0620 ± 0.0059 (n = 7) | 3.417e‐06 |
| ASPA | ||||||
| P19 | 81.3960 ± 7.2522 (n = 3) | 45.4767 ± 6.2821 (n = 3) | .0201 | |||
| Olig2 | ||||||
| P0 | 23.1292 ± 7.0806 (n = 6) | 53.9793 ± 15.4279 (n = 6) | .0992 | 29.5640 ± 5.5861 (n = 10) | 22.8110 ± 4.6375 (n = 5) | .4487 |
| P10 | 34.7171 ± 4.1461 (n = 7) | 67.4031 ± 7.2442 | .0024 | 79.6210 ± 2.7749 (n = 7) | 69.3078 ± 3.2994 (n = 6) | .0345 |
| P19 | 52.3700 ± 9.4416 (n = 3) | 16.3286 ± 16.3286 (n = 11) | .0002 | 32.9730 ± 6.7569 (n = 6) | 10.7081 ± 2.5569 (n = 9) | .0035 |
Values represent OD for MBP, CNPase, and ASPA, and percentage positive cells for Olig2, obtained by quantifying IHC images from BS and SC of P0, P10, and P19‐P21 hPDGFRAfl/+ (Ctrl) and Olig2‐Cre; hPDGFRAfl/+ (KI) mice. p values were determined using two‐tailed unpaired Student t‐test.