Table 2.
Haplotype analysis of IL37 gene SNPs (in the order: rs3811042, rs3811043, rs2466449, rs3811045, rs3811046 and rs3811047) in COVID-19 patients and controls.
| Haplotype | N (Frequency) |
OR | 95% CI | p-value (pc) | |
|---|---|---|---|---|---|
| Patients (N = 100) | Controls (N = 100) | ||||
| A-G-A-C-G-G | 13.05 (0.065) | 11.49 (0.057) | 1.21 | 0.53–2.76 | 0.650 (1.0) |
| A-G-A-C-T-G | 44.09 (0.220) | 51.38 (0.257) | 0.86 | 0.53–1.39 | 0.544 (1.0) |
| G-C-A-C-G-G | 8.77 (0.044) | 5.94 (0.030) | 1.58 | 0.54–4.59 | 0.393 (1.0) |
| G-C-A-C-T-G | 17.61 (0.088) | 14.13 (0.071) | 1.34 | 0.64–2.81 | 0.426 (1.0) |
| G-C-A-T-G-A | 7.17 (0.036) | 3.54 (0.018) | 2.18 | 0.59–7.95 | 0.226 (1.0) |
| G-C-A-T-G-G | 7.70 (0.039) | 9.67 (0.048) | 0.82 | 0.31–2.19 | 0.703 (1.0) |
| G-C-A-T-T-A | 10.98 (0.055) | 1.20 (0.006) | 10.23 | 1.53–68.14 | 0.003 (0.03) |
| G-C-A-T-T-G | 15.55 (0.078) | 15.87 (0.079) | 1.03 | 0.49–2.15 | 0.932 (1.0) |
| G-G-A-C-T-G | 25.16 (0.126) | 40.89 (0.204) | 0.57 | 0.33–1.01 | 0.05 (0.5) |
| G-G-G-T-G-G | 6.06 (0.030) | 9.86 (0.049) | 0.63 | 0.22–1.78 | 0.381 (1.0) |
N: Absolute number; OR: Odds ratio; CI: Confidence interval; p: Two-tailed Fisher's exact probability; pc: Bonferroni correction probability. Significant p-value is bold-marked.