Table 2.
Comparison of baseline and postoperative indices among the three subtype groups in the validation set.
| Total (n = 304) | TD (n = 80) | AR (n = 67) | MX (n = 157) | ANOVA∗ | TD vs. AR∗ | TD vs. MX∗ | AR vs. MX∗ | |
|---|---|---|---|---|---|---|---|---|
| Sex (male/female) | 157/147 | 43/37 | 32/35 | 82/75 | ||||
| Reach MICID in UPDRS-III (n) | 145 (47.7%) | 35 (43.8%) | 45 (67.1%) | 65 (41.4%) | ||||
| Reach MOCID in PDQ-39 (n) | 76 (51.7%) | 41 (41.7%) | 32 (47.8%) | 82 (52.2%) | ||||
| Age at surgery (years) | 60.7 ± 7.6 | 63.5 ± 5.7 | 61.2 ± 10.7 | 60.8 ± 7.3 | 0.178 | |||
| Age at onset (years) | 55.4 ± 6.4 | 52.9 ± 5.5 | 48.3 ± 7.2 | 50.3 ± 5.5 | 0.003 | <0.001 | 0.178 | 0.232 |
| DD (years) | 8.5 ± 2.4 | 8.6 ± 1.8 | 9.1 ± 1.5 | 7.8 ± 3.4 | 0.235 | |||
| Duration of MF (years) | 6.2 ± 2.1 | 3.5 ± 2.1 | 7.3 ± 3.1 | 4.3 ± 2.0 | <0.001 | <0.001 | 0.234 | 0.015 |
| H-Y on | 1.8 ± 1.0 | 2.3 ± 0.9 | 1.7 ± 1.0 | 3.5 ± 0.4 | 0.012 | 0.123 | 0.228 | 0.022 |
| H-Y off | 4.2 ± 1.1 | 3.3 ± 1.8 | 3.1 ± 1.1 | 3.3 ± 1.5 | 0.172 | 0.243 | 0.919 | 0.843 |
| UPDRS-III on | 19.3 ± 7.1 | 18.0 ± 4.8 | 17.4 ± 6.0 | 18..0 ± 5.7 | 0.202 | |||
| UPDRS-III off | 36.6 ± 14.8 | 33.5 ± 11.3 | 41.3 ± 14.6 | 38.6 ± 17.3 | 0.043 | 0.381 | 1.000 | 0.126 |
| LR for UPDRS-III (%) | 50.2 ± 13.5 | 47.3 ± 12.8 | 51.3 ± 12.1 | 53.3 ± 13.8 | 0.371 | |||
| LR for tremor score (%) | 75.2 ± 16.9 | 74.9 ± 11.8 | 75.4 ± 15.2 | 79.0 ± 20.1 | 0.207 | |||
| LR for akinetic-rigid score (%) | 41.5 ± 17.7 | 24.9 ± 20.7 | 43.2 ± 16.6 | 45.4 ± 13.9 | <0.001 | <0.001 | <0.001 | 0.945 |
| LEDD | 955 ± 321 | 873.3 ± 342.2 | 989.7 ± 286.3 | 903.3 ± 222.4 | 0.015 | 0.023 | 0.847 | 0.030 |
| PDQ-39 | 34.7 ± 10.6 | 29.3 ± 7.7 | 37.5 ± 12.9 | 34.4 ± 8.9 | <0.001 | <0.001 | 0.026 | 0.365 |
| HAMD | 10.7 ± 3.6 | 11.4 ± 3.9 | 12.3 ± 3.3 | 12.8 ± 3.6 | 0.333 | |||
| HAMA | 9.9 ± 2.7 | 10.3 ± 1.9 | 12.4 ± 1.9 | 11.5 ± 1.7 | 0.013 | 0.019 | 0.433 | 0.636 |
| Post UPDRS-III on | 13.5 ± 7.8 | 11.1 ± 5.4 | 16.6 ± 8.2 | 12.5 ± 5.0 | 0.003 | 0.002 | 0.936 | 0.012 |
| Post UPDRS-III off | 18.5 ± 7.7 | 14.7 ± 5.7 | 21.2 ± 9.3 | 16.3 ± 6.9 | 0.002 | <0.001 | 0.623 | 0.008 |
| Post PDQ-39 | 30.3 ± 8.9 | 25.2 ± 7.3 | 34.3 ± 8.1 | 28.9 ± 7.3 | <0.001 | <0.001 | 0.023 | 0.078 |
TD: tremor-dominated patients; AR: akinetic-rigid-dominated patients; MX: mixed patients; MICID: minimal clinically important difference; MOCID: moderate clinically important difference; DD: duration of diagnosis; MF: motor fluctuation; H-Y: Hoehn-Yahr stage; UPDRS: Unified Parkinson's Disease Rating Scale; LR: levodopa response; LEDD: levodopa equivalent doses; PDQ-39: Parkinson's Disease Questionnaire-39; HAMD: Hamilton depression scale; HAMA: Hamilton anxiety scale; Post: postoperative; Post UPDRS-III on: on-stimulation/on-medicine; Post UPDRS-III off: on-stimulation/off-medicine. ∗p value. Significant comparisons are highlighted in bold.