Table 3.
Individual differences in pharmacokinetic parameters of hydroxychloroquine and artemisinin in rats.
| Parameters | Hydroxychloroquine, precision (RSD, %) | Artemisinin, precision (RSD, %) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Female | Male | ||||||||
| Low-dose | Mid-dose | High-dose | Low-dose | Mid-dose | High-dose | Low-dose | Mid-dose | High-dose | |
| C max | 32.7 | 18.3 | 30.1 | 72.6 | 44.3 | 84.0 | 78.6 | 102.1 | 72.3 |
| T max | 41.0 | 21.4 | 54.4 | 95.2 | 70.8 | 54.5 | 95.2 | 61.3 | 85.6 |
| t 1/2 | 28.1 | 17.8 | 30.3 | 18.6 | 23.9 | 88.6 | 123.9 | 66.9 | 60.8 |
| MRT0−∞ | 21.6 | 9.6 | 23.7 | 15.4 | 15.0 | 52.0 | 114.1 | 47.0 | 75.7 |
| Vd | 52.4 | 13.7 | 21.5 | 37.4 | 59.7 | 119.0 | 159.1 | 50.5 | 75.0 |
| CL | 23.0 | 11.1 | 28.4 | 42.8 | 45.1 | 43.6 | 54.8 | 72.1 | 92.6 |
| AUC0−t | 20.4 | 9.6 | 21.5 | 41.6 | 47.0 | 61.6 | 88.8 | 137.2 | 74.6 |
| AUC0−∞ | 18.7 | 10.7 | 25.0 | 42.5 | 46.5 | 57.0 | 66.9 | 137.1 | 67.4 |