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Spectral model. Monocytes are transformed into macrophages by stimulation of M-CSF or GM-CSF. Through 28 stimuli from PRR, cytokines, metabolic cues, etc., 299 macrophage transcription programs can be obtained. The results of the study confirm that each stimulus can correspond to a particular structural cluster. Through the analysis of SOM and CCM, 10 main clusters can be summarized, which is the spectral model.
