Table 2.
Pairwise comparison of survival for different tumor progression patterns.
| Recurrence patterns | Whole cohort | Head | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OS | Aps | PFS | OS | Aps | PFS | ||||||||||||||
| Mst | 95%CI | P | Mst | 95%CI | P | Mst | 95%CI | P | Mst | 95%CI | P | Mst | 95%CI | P | Mst | 95%CI | P | ||
| Local progression | Reference | 29.37 | 24.47–39.57 | 15.93 | 11.07–25.03 | 8.97 | 6.40–10.57 | 27.60 | 24.47–37.23 | 15.93 | 9.13–21.53 | 9.13 | 6.90–10.80 | ||||||
| Liver-only metastasis | 20.1 | 17.37–24.63 | 0.214 | 12.60 | 9.83–15.77 | 0.444 | 5.03 | 4.07–6.47 | 0.014 | 20.40 | 17.37–27.90 | 0.413 | 12.13 | 9.83–15.77 | 0.545 | 5.47 | 4.20–6.50 | 0.050 | |
| Lung-only metastasis | 17.33 | 15.33–52.57 | 0.582 | 14.70 | 14.00–30.43 | 0.581 | 5.47 | 2.80–7.47 | 0.680 | 17.30 | 15.33–33.30 | 0.413 | 14.70 | 14.00–17.10 | 0.443 | 2.87 | 2.63–10.60 | 0.720 | |
| Other metastases | 23.97 | 10.77–23.97 | 0.863 | 11.23 | 1.63–29.45 | 0.154 | 12.73 | 9.13–28.70 | 0.239 | 16.13 | 13.55–18.27 | 0.538 | NA | NA | NA | 12.13 | 10.24–15.27 | 0.532 | |
| Local + distant metastasis | 24.87 | 8.50–34.87 | 0.247 | 7.20 | 3.67–11.57 | 0.115 | 5.60 | 1.73–7.60 | 0.025 | 24.11 | 10.13–30.22 | 0.094 | 4.17 | 2.63–11.57 | 0.078 | 6.53 | 2.10–8.67 | 0.089 | |
| Multiple metastases | 17.50 | 11.20–19.50 | 0.006 | 9.20 | 8.10–12.63 | 0.023 | 5.70 | 3.80–8.30 | 0.017 | 17.50 | 13.80–19.50 | 0.049 | 9.20 | 8.10–12.63 | 0.121 | 5.70 | 2.70–8.63 | 0.023 | |
| Liver-only metastasis | Reference | 20.1 | 17.37–24.63 | 12.60 | 9.83–15.77 | 5.03 | 4.07–6.47 | 20.40 | 17.37–27.90 | 12.13 | 9.83–15.77 | 5.47 | 4.20–6.50 | ||||||
| Lung-only metastasis | 17.33 | 15.33–52.57 | 0.92 | 14.70 | 14.00–30.43 | 0.676 | 5.47 | 2.80–7.47 | 0.285 | 17.30 | 15.33–33.30 | 0.627 | 14.70 | 14.00–17.10 | 0.752 | 2.87 | 2.63–10.60 | 0.496 | |
| Other metastases | 23.97 | 10.77–23.97 | 0.562 | 11.23 | 1.63–29.45 | 0.225 | 12.73 | 9.13–28.70 | 0.036 | 16.13 | 13.55–18.27 | 0.452 | NA | NA | NA | 12.13 | 10.24–15.27 | 0.250 | |
| Local + distant metastasis | 24.87 | 8.50–34.87 | 0.47 | 7.20 | 3.67–11.57 | 0.286 | 5.60 | 1.73–7.60 | 0.931 | 24.11 | 10.13–30.22 | 0.479 | 4.17 | 2.63–11.57 | 0.171 | 6.53 | 2.10–8.67 | 0.773 | |
| Multiple metastases | 17.50 | 11.20–19.50 | 0.082 | 9.20 | 8.10–12.63 | 0.092 | 5.70 | 3.80–8.30 | 0.076 | 17.50 | 13.80–19.50 | 0.149 | 9.20 | 8.10–12.63 | 0.240 | 5.70 | 2.70–8.63 | 0.855 | |
| Lung-only metastasis | Reference | 17.33 | 15.33–52.57 | 14.70 | 14.00–30.43 | 5.47 | 2.80–7.47 | 17.30 | 15.33–33.30 | 14.70 | 14.00–17.10 | 2.87 | 2.63–10.60 | ||||||
| Other metastases | 23.97 | 10.77–23.97 | 0.678 | 11.23 | 1.63–29.45 | 0.125 | 12.73 | 9.13–28.70 | 0.309 | 16.13 | 13.55–18.27 | 0.558 | NA | NA | NA | 12.13 | 10.24–15.27 | 0.326 | |
| Local + distant metastasis | 24.87 | 8.50–34.87 | 0.491 | 7.20 | 3.67–11.57 | 0.436 | 5.60 | 1.73–7.60 | 0.061 | 24.11 | 10.13–30.22 | 0.553 | 4.17 | 2.63–11.57 | 0.408 | 6.53 | 2.10–8.67 | 0.799 | |
| Multiple metastases | 17.50 | 11.20–19.50 | 0.275 | 9.20 | 8.10–12.63 | 0.022 | 5.70 | 3.80–8.30 | 0.577 | 17.50 | 13.80–19.50 | 0.718 | 9.20 | 8.10–12.63 | 0.025 | 5.70 | 2.70–8.63 | 0.734 | |
| Other metastases | Reference | 23.97 | 10.77–23.97 | 11.23 | 1.63–29.45 | 12.73 | 9.13–28.70 | 16.13 | 13.55–18.27 | NA | NA | 12.13 | 10.24–15.27 | ||||||
| Local + distant metastasis | 24.87 | 8.50–34.87 | 0.334 | 7.20 | 3.67–11.57 | 0.686 | 5.60 | 1.73–7.60 | 0.016 | 24.11 | 10.13–30.22 | 0.273 | 4.17 | 2.63–11.57 | NA | 6.53 | 2.10–8.67 | 0.223 | |
| Multiple metastases | 17.50 | 11.20–19.50 | 0.108 | 9.20 | 8.10–12.63 | 0.998 | 5.70 | 3.80–8.30 | 0.002 | 17.50 | 13.80–19.50 | 0.617 | 9.20 | 8.10–12.63 | NA | 5.70 | 2.70–8.63 | 0.030 | |
| Local + distant metastasis | Reference | 24.87 | 8.50–34.87 | 7.20 | 3.67–11.57 | 5.60 | 1.73–7.60 | 24.11 | 10.13–30.22 | 4.17 | 2.63–11.57 | 6.53 | 2.10–8.67 | ||||||
| Multiple metastases | 17.50 | 11.20–19.50 | 0.701 | 9.20 | 8.10–12.63 | 0.958 | 5.70 | 3.80–8.30 | 0.910 | 17.50 | 13.80–19.50 | 0.879 | 9.20 | 8.10–12.63 | 0.770 | 5.70 | 2.70–8.63 | 0.637 | |
NA, not available; other abbreviations as in Table 1.